ID A0A498LQ48_LABRO Unreviewed; 540 AA.
AC A0A498LQ48;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Paired box protein Pax-8 {ECO:0000256|ARBA:ARBA00039822};
GN ORFNames=ROHU_010943 {ECO:0000313|EMBL:RXN09872.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN09872.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN09872.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN09872.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN09872.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN09872.1}.
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DR EMBL; QBIY01013224; RXN09872.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LQ48; -.
DR STRING; 84645.A0A498LQ48; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR022130; Pax2_C.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF6; PAIRED BOX PROTEIN PAX-8; 1.
DR Pfam; PF00025; Arf; 1.
DR Pfam; PF00292; PAX; 1.
DR Pfam; PF12403; Pax2_C; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00351; PAX; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 174..300
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
FT REGION 316..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 58765 MW; 1922645FF4FB41B1 CRC64;
MKNSPEQEVR ILLLGLDNAG KTTILKQLAS EDISHITPTQ GFNIKSVQSQ GFKLNVWDIG
GQRKIRPYWR NYFENTDLLI YVIDSSDRKR FDETAQCHNS PTERQSHNLH HHPLITAPHA
AMIKAKQCEP ELLTCRPSGA QTVNVGGGGQ RSHLSVGHGT VRWAQRGSSV LFEGHGGLNQ
LGGMFVNGRP LPEVIRQRIV DMAHQGVRPC DISRQLRVSH GCVSKILGRY YETGSIKPGV
IGGSKPKVAT PKVVEKIAEY KRQNPTMFAW EIRDRLLAEG VCDGDTVPSV SSINRIIRTK
VQQPFNLPLD SKGLSPGHTL IPSSAVTPPE SPQSDSLGST YSISGLLGIP QTSTEGKRSH
DDSDQESCRH SVDSQGSGSG PRKQLRTEHF PSPHLDCGFE RHHYSSDTFS QTAASKTEQS
LYPLSLINGS LDEGKGASAI SRNLAAHQGY TVVAGRDVAS SMLPGYPPHI PSATQTGFSS
STITGMVAGP EYTGQTYSHA PYTSYSDAWR FTNSSILGSP YYYSSAARAP PPSTAAYDHL
//
