ID A0A498LRY5_LABRO Unreviewed; 947 AA.
AC A0A498LRY5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Flap endonuclease GEN-like protein {ECO:0000313|EMBL:RXN08227.1};
GN ORFNames=ROHU_011667 {ECO:0000313|EMBL:RXN08227.1}, ROHU_028818
GN {ECO:0000313|EMBL:RXN14250.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN08227.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN08227.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN08227.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN08227.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN08227.1}.
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DR EMBL; QBIY01013327; RXN08227.1; -; Genomic_DNA.
DR EMBL; QBIY01012911; RXN14250.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LRY5; -.
DR STRING; 84645.A0A498LRY5; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041012; GEN_chromo.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR Pfam; PF18704; Chromo_2; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000313|EMBL:RXN08227.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 168..263
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 291..357
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..718
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..894
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 104658 MW; 8A3403F3412E8137 CRC64;
MLTFLRKLKK SDTSNSCPEF RPAGQIKEIQ TRGGRGKSAG GPAHSPSPQP RTALLSQEPL
RESLDILTSV EYSRCELQPR PSRIPVRRDI QSAGLPPAAS ETPTMRVWKL IKPGIKKHLA
GVSGKDGSSL RLATKALLKS SSCSYESSGD KHAHSDLMFV VCVLEVIMGV SELWSILDPV
RQSVPLYSLS GKTLAVDLSL WVCEAQHVQG MMGKVTKPHL RNLFFRVSSL TLMGVKLVFV
MEGDAPRIKA ETMSKRTEMR YGSAKTKPAA AKNTGRGRFK AVLRECAEML DCLGVPWVTA
AGEAEAMCAY LDSQGVVDGC ITNDGDAFLY GAQTVYRNFN MNTKVHTAVL VSTQMSNACP
NTSRVVIPQD PQVDCYRTSR VQAELGLSRD TLVGLAVLLG CDYIPKGVSG VGKEQTLKLI
QNLKGKSLLQ KFTEWDADRA ERSEVAVKKV THCLVCRHPG SAKAHERGGC AFCESERFCS
PQDYDSQCPC EWHRTERTRQ ASSVEAGIKK KALACEQFPF TEIISEFLVT KDKPVQAFRR
RKPNLQLMQT FALEKMDWPK HYSSEKVLVL MTYTELMNRK HGRDSQAQIQ PIRIYKPRVR
NGVSCFEVIW KKPDHYVFAE GCEEQTEVRT VEEESLFGLA FPGIVRDFQR DRAEAQENKT
KKKKPKVKKE KPAVSHDAVS DLFAQMSLQT DADPDPGSTQ NPPQPDSPPS PEIQPPPPSQ
NSLSESALIG QLHLSSIDWD SSSFTASPSQ KPQSGKTDLR PAENTACSLK ERIIVKNTPK
QQQTGPESKV DDRRSIPSVL SKVPKTKTNT TAKTTKNPFR PAARPPKGVS GRCNPTANSK
TVCKTSPVSD DSDAENRPGS HKRRNDVKAT SKPPKTGPTD PLRQQKSGRN EQMSVRAAKT
PEKESHAPVR PAKPIQVHRG TVEEDDSDAS LDSPRPLAER LKMRFAK
//
