ID A0A498LU65_LABRO Unreviewed; 1296 AA.
AC A0A498LU65;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=KIBRA-like protein {ECO:0000313|EMBL:RXN10656.1};
GN ORFNames=ROHU_030496 {ECO:0000313|EMBL:RXN10656.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN10656.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN10656.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN10656.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN10656.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN10656.1}.
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DR EMBL; QBIY01013186; RXN10656.1; -; Genomic_DNA.
DR STRING; 84645.A0A498LU65; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:UniProt.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF22; PROTEIN KIBRA; 1.
DR Pfam; PF04857; CAF1; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498LU65};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 28..61
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 632..755
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 109..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 334..368
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 110..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 817..834
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1296 AA; 146129 MW; 77570C4081A15FF0 CRC64;
MYGRVKRSSR GSICRQTKPL TFADCIGDEL PVGWEEAYDP HIGAYYVDHN TKSTQLEDPR
AQWQREQELM LRDYLNVVQE ALSAQKEIYQ VKEQRLHLAQ QEYRQLNDAW RDKSSSQTSL
NSRSSSSSKY DPEILKAEIV TAKSRVNKLK RDLACMRQEL LYKEQGFETL KEIDHKVSSA
SHGYKLHEAQ AILKEVKTIK DAISSGEKEK QELMQKLAVL KDGFQLEYGS QSDLWASNPS
LANSNLSLPR LYSDAESQTD VPAEFVSNSN KLAEKVRLSL KYEEAKRRIA NIEVQIAKLD
SEAWPGLLDP ERDRLILINE KEELLKELQY VTPCKRAPSE AEKIETEKKR LEKDLQAARD
NQSKALTERL KLHYRRNKLV KELEETVRLA SSLHTQLKSL SASTLSCSSG SSRGSLTSSR
GSLANSSLGS TSSLSFTDIY LEQPELGDPD FQNKLDSILQ EGSSSGYRPS SSITTIHENE
VSSSSRQVGS GPGMGQRTQV LRLSETPLSM SSLSPRSSLS SLSPPCSPLV TDASFLSGEA
FSGPASQLDL DLQTRLMELR LEEDHQQGAV ESLKDAVTQT RMSGPGSKKA GVTSAVSDES
VAGDSGVYEP SEKRSGLPVE QQLGYDDGSS ASSSQIKLGL KYEAKDKRFT VFVMQLSNCS
ALSLPANQNI YIRVVVLPCS EPVRCLFRTH GALPQEPLEF KEAFSLQMSS AALRQKTLRV
DVCSTRKSGR EDCLASAQIS LADEEYSEEW CTKWYNLLNC TYLPEMDGKH KETEGSVQQE
LISAPSTSES TVARLENASL EDCPTEALEG DVFLDEEGSD GEEDEEFYPD DCQWEQEEEP
VKPGPTAVIT EKVNKETSVD GLPHSASVVR PKERRHDVHQ QNPFMRGNTI IRSKTFSPGP
QSQYICRINR SDSDSSTLSK KSPFVRNASE RRSVRMKKPQ MQIKGLDGLL RTSLDLELDL
QVSRTRHSRL NEELHVLREL KEQLESARQQ GQHVLPTWVQ EDERFRLLLK HTERQTHEEQ
LQEKRVEKMM RAAAKDVHKI RGQSLKEVPG DTEFPGVVVR PIGEFRSTVD YQYQLLRCNV
DLLKIIQLGL TFMNEDGDYP PGTTTWQFNF KFNLTEDMYS QDSIDLLQNS GLQFKKHEEE
GIDTLYFAEL LMTSGLVLCE NVKWLSFHSG YDFGYLVKLL TDSRLPEEEH EFFQILNLFF
PAIYDVKYLM KSCKNLKGGL QEVADQLELK RIGRQHQAGS DSLLTGMAFF RMKELFFEDN
IDDAKYCGRL YGLGSGSSQS QNGISNSSQE ETNNKH
//
