ID A0A498LXQ5_LABRO Unreviewed; 769 AA.
AC A0A498LXQ5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=ROHU_029217 {ECO:0000313|EMBL:RXN13010.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN13010.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN13010.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN13010.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN13010.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN13010.1}.
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DR EMBL; QBIY01013015; RXN13010.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498LXQ5; -.
DR STRING; 84645.A0A498LXQ5; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 3.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF04548; AIG1; 2.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 232..443
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
SQ SEQUENCE 769 AA; 87719 MW; 7273F20A86E6C5D1 CRC64;
MDLPIKTEQC ESDSSDSSMD NMFPSMTIVL FGYSSSVQYR NDNILLGEKK NIENEISRIV
PLERKISECD ISVINMVDLH KTEHVDNLLS KLMNKNEIHA FIFVVPLGQL TNDDKMSLDW
LQKVFGDKVL QFVMILFTYE GEEECNTVKD DLRRNPDLQQ LLDKCRGRYQ TCNKMMNNQS
EMRDLMKKIE HLFNENQQQS YTGEMFKTAS IRRKELENSE HRCGHTSEME PNAQLNLILL
GKHRAGKSAS GNTILGQKAF VKKNSKSVTR EVAVKSGTVN GFSVTVYDTP GFHDPKMSTE
EIQQILEKVI QKCESGLCVF LLVIKADNFT EEERETVEKI EKLLGEKRLE KTWILFTRGD
ELQEENKTII EFINETEALK KLIQKYNQKY HVFNNKKKGR SDQARLLLVN ILQSGLGEVR
QPYVISLKPG ATPFSLKTPR RIPLPLMGKV KEELHRMEML GVISRVEEPT DWCAGMVVVP
KKSGAVRICV DLSKLNESVR RKKYILPSVE QTLGMLAGAQ IFSKLDANMG FWQIPLSEES
ARIEWLPEVT DGLEGTVCHI DDVLVWGRTE EEHDSRLHVV LEKMQKAGIT LNVEKCKLSK
RKVHFLGHII SAEGISPDPM KTAAIRNMTE PSNVSELRSF LGMVNQLGRF IPQLADKDKA
LRDLLSKKNC WIWGMEQAKA FQTLKDSLSS PPVLAIYDTN RDCKVSADAL PYGLGAVLMQ
RWQDGWKPIA YASRSLTQTE QRYAQVDAKD SETFLLASTL KWRPITSHY
//
