ID A0A498MB05_LABRO Unreviewed; 1748 AA.
AC A0A498MB05;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Nuclear pore complex protein Nup93 {ECO:0000256|ARBA:ARBA00017717};
DE AltName: Full=93 kDa nucleoporin {ECO:0000256|ARBA:ARBA00033360};
DE AltName: Full=Nucleoporin Nup93 {ECO:0000256|ARBA:ARBA00033068};
GN ORFNames=ROHU_026422 {ECO:0000313|EMBL:RXN18278.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN18278.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN18278.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN18278.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN18278.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004617}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004617}. Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- SIMILARITY: Belongs to the nucleoporin interacting component (NIC)
CC family. {ECO:0000256|ARBA:ARBA00010186}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN18278.1}.
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DR EMBL; QBIY01012722; RXN18278.1; -; Genomic_DNA.
DR STRING; 84645.A0A498MB05; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1901702; F:salt transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IEA:InterPro.
DR GO; GO:1902476; P:chloride transmembrane transport; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR017854; Metalthion_dom_sf.
DR InterPro; IPR018064; Metalthion_vert_metal_BS.
DR InterPro; IPR007231; Nucleoporin_int_Nup93/Nic96.
DR InterPro; IPR018491; SLC12_C.
DR PANTHER; PTHR11225:SF4; NUCLEAR PORE COMPLEX PROTEIN NUP93; 1.
DR PANTHER; PTHR11225; NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF04097; Nic96; 1.
DR Pfam; PF03522; SLC12; 3.
DR SUPFAM; SSF57868; Metallothionein; 1.
DR PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851};
KW mRNA transport {ECO:0000256|ARBA:ARBA00023132};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00023132};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498MB05};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023132}.
FT TRANSMEM 1039..1065
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1085..1109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1130..1149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1304..1323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1384..1403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 923..992
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 1011..1193
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 1209..1444
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 1453..1591
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1621..1681
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1678..1747
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 965..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1748 AA; 195141 MW; A91B46ED12311D39 CRC64;
MDPCDCSKTG TCSCGATCKC TNCQCTTCKK MKITLLLLYN RNKGNWNVLQ TVEQVLHMDT
EGFGELLQQA EQLAAETEAV SELPHVERNL QEIQQAGERL RSRTLTRTSQ DTADVKASIL
LGSRGLDIFH ISQRLESLSA ATTFEPLEPV KDTDIQGFLK NERDNALLSA IEESRRRTFL
LAEEYHRDSM LVQWEQVKQR VLHTLLGAGE DALDFSQEVE PSFVSEVGVP GRSALDSVEV
AYSRQIYVFN EKIVNGHLQP NLGDLCASVA ESLDDKNVSD MWLMVKQMTD VLLVPAKDTL
KSRVSVDMQM AFVRQALQFL ENSYKNYTMV TVFGNLHQAQ LGGVPGTYQL VCSFLNIKLP
TPLPGMQDGE VEGHSVWALI YFCLRCGDLS AAMQVVNRAQ HQLGDFKIWF QEYMNSPDRR
LSPATENKLR LHYRRVLRNS ADPYKRAVYC LIGKCDIGDN HGEVADKTED YLWLKLNQVC
FDEDGSSSPQ DRMTLAQLQK QLLEDYGESH FSASHQPFLY FQVLFLTAQF EAAIAFLFRV
ERLRSHAVHV ALVLYELKLL LKSSGQSAQL LSQEAGDPPM VRRLNFIRLL MLYTRKFEST
DPREALQYFY FLRNEKDSQG ENMFMRCVSE LVIESREFDM LLGRLEKDGS RKPGVIDKFA
GDTRVIITKV ASEAENKGLF EEAVKLYELA KNPDKVLELM NKLLSPVIAQ VSEPQSNKER
LKNMAVAIAE RYRTNGVAGE KSVDSTFYLL LDLMTFFDEY HAGHIDRAYD VIERLKLVPL
SQDSVEERVA AFRNFSDEIR HNLSEVLLAT MNILFTQYKR LKGAVAGTPG RPQRTLEDRD
MLLRSKARAL ITFAGMIPYR MAGDTNARLV QMETAVDSIV LEVLQANDGM NLTSARSPFS
VSSLSNGDDR KFSLGGCSSY DTDSVASRSS GVFSGYDTLD TPPSYDFYTN TEVFGRAKKS
RPSLFQLHSN PQDDPSPPPL YEETNVDKQS PDEDEPTEPP PEPTRFGWAQ GVMIRCMLNI
WGVILYLRLP WITSQAGIGL TWIIILVSSS ITGITGLSTS AIATNGKVKG GGTYFLISRS
LGPELGGSIG LIFAFANAVA VAMHTVGFAE TVQALMQETD VSMVDKLNDI RIIGVITVTC
LLAISMAGME WESKAQVLFF LVIMISFASY IVGTIIPATP QKQAKGFFSY RGSCVLRDAS
GYINDTVSSL SGECLGVGCN YGWNFTECMT NRTCPFGLSN YYQSMSMVSA CAPLISAGIF
GATLSSALAC LVSAPKVFQC LCKDKLYPGI GFFGKGYGKN NEPLRSYLLA YVIAICFILI
AELNTIAPII SNFFLCSYAL INFSCFHASI TNSPGWRPTF RFYSKWLSLL GAVVSVIIMF
LLTWWAALIA IGIVIFLLGY VLYKKPDVNW GSSMQASSYN MALSQCVGLN QVEDHIKNYR
PQCLVLTGPP CMRPSLVDFI STFTKNQSLM ICANVIGGGP SPGGGDSAKI STHLKWLDKR
RIKSFYHTVV ADDLRVGVQM LLQSTGLGRM KPNVLVMGFK KNWRKAQPSN IDNYIGILHN
AFDLQYGVCV LRMKEGLDIS RTMQAQVNLG FETSTEQGLD TRTSTATPAT IDISLDPEEL
MAATQPTTVF QTRQGKKYID VYWLSDDGGL TLLLPYLLTR KKRWGRCKVR VFVGGEAQQS
LRQIRLNEVI QDYSRDAALI IVTMPVGRRE TCPSPLYMAW LEIVSRDLRP PVLLVRGNQE
NVLTMYCQ
//
