ID A0A498MCD5_LABRO Unreviewed; 1599 AA.
AC A0A498MCD5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Hepatic triacylglycerol lipase-like protein {ECO:0000313|EMBL:RXN17483.1};
GN ORFNames=ROHU_037000 {ECO:0000313|EMBL:RXN17483.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN17483.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN17483.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN17483.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN17483.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN17483.1}.
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DR EMBL; QBIY01012744; RXN17483.1; -; Genomic_DNA.
DR STRING; 84645.A0A498MCD5; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00333; MIP; 1.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 2.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR002333; Lipase_hep.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46349:SF6; MYOSIN_TAIL_1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00151; Lipase; 1.
DR Pfam; PF00230; MIP; 2.
DR PRINTS; PR00824; HEPLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF81338; Aquaporin-like; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 962..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1016..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1142..1453
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1108..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1599 AA; 179640 MW; 42ABF0AF8E5C592B CRC64;
MESFGAQDGR SQSDPVRASQ DDSGSFGVQV QVQGISGRPY VVLNAQGRRV PRSPEYPDVF
LAEHRRQEFV SNMSGGASST QTPRPDHHRS LRVFKNPSVQ LLNYQRNPEI LKPYDPRNSR
GWCSSPSSPV MVKRARIPVP GAGRDRVQEP AVESVPCQPS HIICRMSVPA SETYDTGTAS
AGSPRTGRVG HRGRIAPEEK RRSRSLESRS DGIRTEVGGF AQSGQGERSE VNEENGSGQA
TPDLLKGRRE LPDQPDEETA KLVMVNYLKD GSCEGEAVIR QRVELMFDKI HMLKFRALEE
FAFAAPLEEV NDLKDRRAAL ERHVSLLQQQ LQEAKQDSDG LSEEKEETNA ELKRLQEALE
RSEQEQITLR HKLTDMEKEL QTSLDQLLQA RRARDQCRSD MRDLQQQLSD IHDELDSAKS
CEAGERDRLL QDLSELRGEF EALQRVQEEQ EEALHRRDRE LTALRGALEE EISAHARDVE
ALQEEHQQEI HRLLEATQEA KEAPDSTRLR PPPLLQSVAL LGQKVLEVAA EKGAGQTLIA
ELKQTKAELQ LKISALEEQI SSLDHLIQQK QEQEKLLTER VEQLTMEKRN LEEELQEVRQ
QEDDMCGANR ALMRHLEDTQ GELSRLTRAH RELKERFEEE RRRTEELQRR RSELEEERRS
QDRVLERLHD EMSAAVTGSE QETQRLQEEN KDLRGRVSQL EGSQRLGQDA VVSELQLHVQ
ELEERLLGEE KEKSDLQQLN RRLERRMKEL TLHLEEEKLS LQDQRDQRQL DEAEEEIERL
ENSRKKLQRD VEEQQEISDQ LKTEICGLRN HISPVRRTRS IMKHHCALKH GIFKEFLAEF
LGTFVLVLFG CGSVAQTVLS RNTLGEPLTV HIGFSTGLMM GVYVAGGVSG NTHTHTHTHT
GYISITHRNS SALTREPEPQ ASDHCLSQNR SINRIHSSFC GHLNPAVSLA MVILGKLKIW
KFPIYVAAQM LGAFVGAAAV FGLYYDAFMD FTSGILSVTG INATGHIFAS YPGRHLTVLG
GFVDQVVGTG MLVLCILAVV DGRNIGAPHG VEPLAVGLIL LGISVSMGLN CGYPLNPARD
LGPRLFTAAA GWGMEVFRLS FSGSRADADP QEKLLTPPDD HESPERFTPH DCRHSASETH
SAPPVKTVLK SSFHLYHEGS VFEETCAVVP FRSETLHSCA YNHGDPLVMI IHGWKINGLM
ETWIFDLASA LKVRLGRVNV FISDWRSLAR QPYPIAAKNS RQVGQDVATL LKWLEEVAQL
SMDDVHLIGY SLGAHVAGFA GSHFRGLRKV GRITGLDPAA PHFEGLPAFD RLSPDDAQFV
DAIHTFTGNS FMPGVGIKQS VAHVDFYPNG GSFQPGCKML DIYSNVFQYG LEGVPKTIKC
AHERAVKLFT DSLVNASQPI IGYRCRDDST FNKGLCLDCK QMRCNTLGFD VRRERVGRNA
KGLYLRTGPQ VPYRVFHYQI RVLLKNLIEP VEASLSVTLN GTGGESPELP IILHQESTGL
KSFSSLLAVA SDLGQLSSVR LVWKGELVWS NWMRRVRNIM NWNTSDQDTE LSVWRICIKS
GESQEKMWFC GASAGVSRLR ISEEQEFRRC QSSSSPSQT
//
