ID   A0A498MCM7_LABRO        Unreviewed;       694 AA.
AC   A0A498MCM7;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Growth differentiation factor 10-like protein {ECO:0000313|EMBL:RXN17563.1};
GN   ORFNames=ROHU_026843 {ECO:0000313|EMBL:RXN17563.1};
OS   Labeo rohita (Indian major carp) (Cyprinus rohita).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Labeoninae; Labeonini; Labeo.
OX   NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN17563.1, ECO:0000313|Proteomes:UP000290572};
RN   [1] {ECO:0000313|EMBL:RXN17563.1, ECO:0000313|Proteomes:UP000290572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN17563.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:RXN17563.1};
RA   Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA   Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA   Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA   Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA   Shah T.M., Rai A., Jena J.K.;
RT   "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXN17563.1}.
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DR   EMBL; QBIY01012743; RXN17563.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498MCM7; -.
DR   Proteomes; UP000290572; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR017948; TGFb_CS.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR   PANTHER; PTHR16059:SF16; ANTHRAX TOXIN RECEPTOR-LIKE; 1.
DR   Pfam; PF05586; Ant_C; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT   DOMAIN          276..346
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   REGION          327..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          622..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..694
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  79525 MW;  FAEBD8AA43B2EE20 CRC64;
     MLKLYEKYNI EPNRLKEGNT VRSFKAKPEN VEERVSYWLN LTSLQGSEVI LTSTFHFFVD
     KRPRQRSWFC KRLKNPSCRI PDLHLLPSVR LLFRSASGTL LGNITVVPHR RGTWQSKDVS
     VIIKEARDKN HLLITVEFDY GEQYQRYQDQ LPQSSLPYLL VYANDLAISE PNSVAVSLQR
     YDPFVADQQP TRSPDSAPDI RVKRELDLDF SDPIENNELP EVEYNSFKQH DMWESAYFAL
     KPKPFKKERR RKGQEHADGF GKSQVLRFDE KTMKKARRRQ WKEPRSCSRR YLKVDFADIG
     WNEWILSPKS FDAFYCAGTC EFPIPKVSEP HGEDQRGPPL QPCNHPEHSQ GRWDNSRSGS
     VKNHWNEIYF FVEHLAEKFI SPMLRMSFIV FSTQGTTIMK LTENRNEITR GLNILKREIP
     GGDTYMNLGL KKAQRARSLG AIVYCVGVKD FNQTQLATIA DTIEHVFPVL GGFQALEGMI
     DSVIKEVPPP PPPEPESDDE DGMPKKKWPT VDASYYGGRG VGGIKRMEVR WGNKGSTEEG
     AKLEMPKNAV VKMPEDEYEP YEPKLRNPYG RRPAHHRKWY SPIKGKLDAL WALFRRGYDQ
     VSLMRPQPGD QGRCINFTRV KAEEPRSPPH SNCPLPPPPP PPDHQPLMRP PPKRPPSRGP
     SINRSPPGPP PARAPPGPRR PPPSRPPPCP GNGH
//