ID A0A498MDP4_LABRO Unreviewed; 898 AA.
AC A0A498MDP4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
GN ORFNames=ROHU_036968 {ECO:0000313|EMBL:RXN18330.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN18330.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN18330.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN18330.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN18330.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC IRES-mediated translation during mitosis, apoptosis and viral
CC infection. Cleaved by some caspases and viral proteases.
CC {ECO:0000256|ARBA:ARBA00037759}.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN18330.1}.
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DR EMBL; QBIY01012722; RXN18330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MDP4; -.
DR STRING; 84645.A0A498MDP4; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 1: Evidence at protein level;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Initiation factor {ECO:0000313|EMBL:RXN18330.1};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Protein biosynthesis {ECO:0000313|EMBL:RXN18330.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498MDP4};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 535..658
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 712..895
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 12..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..503
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 102091 MW; E833ECA511815580 CRC64;
MPLKVAAWDI SASSGGGGGR GAPQHYPKTV GNSEYLGKTP GPSVQRWVPS RSTRRDVNSS
NEKEHHDAIF RKVRGILNKL TPEKFDKLCL ELLNVGVDSK LVLKGIILLI VDKALEEPKY
SSLYAQLCLR LAEDAPNFDG PTPEIQSSQK QSTTFRRLLI TKLQDEFENR TKNVDIYDKQ
DNPLTSEEEE QRAIAKIKML GNIKFIGELG KLDLIHESIL HKCIKTLLEK KKRVQLKDMG
EDLECLCQIM RTVGPRLDHE KAKSLMDQYF GRMRSLMNNK DLPARIRFLL QDTVELRENN
WVPRKAFIDN GPKTINQIRQ DAVKDLGVFI PPMNQGLRMD FFLEGPFMPN RMKLDRETLG
GLADMFGQMP GSGIGTGPGV IQDRFSPTLG RHRTNPLFNG HSGHMASQPQ SQFDLGMKPF
IKSNQGQNQH FHNQNQNHSN QQQAQSKDMP PRFKKGQLNA DEISLRPAQS FLMNKNQVPK
LQPQIPTMIP PSAQPPRTQT PPLGQPPQLG LKTNPPLIQE KPQKTTKKPA PTKEELLKMT
ENVVTEYLNS KNMEDAVSGV KEMKAPKHFL PEMLSKIILC SLERTDEDRE QASTLIHTLR
TEGFITGENF MQALLNVLDQ CPKIEVDIPL VKSYLAQFAA RAVIAELVSV AELAHPLENG
NHFPLFLLCL QQASKLKDRE WLTDLFQQSK VNMQKMLPEI DQNKDRMLEV LEGKGLSFLF
PLLKLEKELL MQIKTDPSPQ AIYKWIKDNI SPKLHTDKGF INILMTSFLH YIFAELGVNE
GDEQLASPSK EQLDQEKQLL LSFKPVMQKF LHDHPDLQVS ALYALQVHCN ASAFPKGMLL
RYFVNFYDME IIEEEGFLAW KEDISQEFPG KGKALFQVNQ WLTWLETAEE EESEEEAD
//
