ID   A0A498MKX8_LABRO        Unreviewed;       619 AA.
AC   A0A498MKX8;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Rho GTPase-activating 17-like isoform X3 {ECO:0000313|EMBL:RXN19994.1};
GN   ORFNames=ROHU_025296 {ECO:0000313|EMBL:RXN19994.1};
OS   Labeo rohita (Indian major carp) (Cyprinus rohita).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Labeoninae; Labeonini; Labeo.
OX   NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN19994.1, ECO:0000313|Proteomes:UP000290572};
RN   [1] {ECO:0000313|EMBL:RXN19994.1, ECO:0000313|Proteomes:UP000290572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN19994.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:RXN19994.1};
RA   Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA   Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA   Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA   Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA   Shah T.M., Rai A., Jena J.K.;
RT   "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXN19994.1}.
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DR   EMBL; QBIY01012653; RXN19994.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498MKX8; -.
DR   STRING; 84645.A0A498MKX8; -.
DR   Proteomes; UP000290572; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd04386; RhoGAP_nadrin; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR004148; BAR_dom.
DR   InterPro; IPR047165; RHG17/44/SH3BP1-like.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR14130; 3BP-1 RELATED RHOGAP; 1.
DR   PANTHER; PTHR14130:SF3; RHO GTPASE-ACTIVATING PROTEIN 17; 1.
DR   Pfam; PF03114; BAR; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00721; BAR; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS51021; BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT   DOMAIN          14..253
FT                   /note="BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51021"
FT   DOMAIN          255..445
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          463..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..619
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          169..196
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        561..576
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..619
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   619 AA;  68077 MW;  5C1DF5FD9F3EA4E3 CRC64;
     MKKQFNRMKQ LANQTVGRAE KTEVLSDDLL MIERRLENVR LVSHNVHKKI IMCMQGNVGS
     DAEKRHKKLP LTALSQSMLD GVGQLGDESL IAKMMEVCGE AENKLALEQS QHEVQLERDI
     LEPLNQLAEV DIPNILKQRK HLAKLVLDFD SAKARYHQAT KAYPSAANAQ AMAAKVDTLK
     EEMDEAQNKM EICKDQVAAD MYNFYSKEGD YARYYVLLLE AQAEYHRKAL ASIESVLPTI
     QSQQDKWTEK PAFGTALEEH LKRTSREIAL PIEACVMMLL ETGMQEEGLF RIAAGASKLK
     KLKAALDCST SQLEEFYSDP HAVAGALKSY LRELPEPLMT YQLYEEWIQA SNIADPDKRL
     QALWVVCDML PKANKTNFRY LVKFLAKLAL ESDTNKMTAS NIAIVLGPNL LWAKTEGSLA
     EMAATTSVHV VSIIELIINH ASWFFPEDVD FNVSGVFAMP GCPGTPDSEA GTIDRRRPGS
     QGSFEYDIPR KDSPANKQPE IAPRRAGTVT KKQHSTPNFQ PPLPPIDDGG VPVFEPSPLS
     PTGGGLEAGQ AGAVLPQTHQ PLVQQTAENS NIVRDPASTP PALRNGPGGS GGTPAQLNVV
     TPTSGPKGPS PFMSRRGQS
//