ID A0A498MKZ6_LABRO Unreviewed; 864 AA.
AC A0A498MKZ6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Interferon regulatory factor 2-binding 1 {ECO:0000313|EMBL:RXN20900.1};
GN ORFNames=ROHU_024622 {ECO:0000313|EMBL:RXN20900.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN20900.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN20900.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN20900.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN20900.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the IRF2BP family.
CC {ECO:0000256|ARBA:ARBA00010802}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN20900.1}.
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DR EMBL; QBIY01012628; RXN20900.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MKZ6; -.
DR STRING; 84645.A0A498MKZ6; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.10.1580; Interferon regulatory factor 2-binding protein; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR044882; I2BP1/2_C3HC4-RING_sf.
DR InterPro; IPR022750; Interferon_reg_fac2-bd1_2_Znf.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10816:SF14; E3 UBIQUITIN-PROTEIN LIGASE IRF2BPL-RELATED; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR Pfam; PF11261; IRF-2BP1_2; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 256..306
FT /note="Interferon regulatory factor 2-binding protein 1 & 2
FT zinc finger"
FT /evidence="ECO:0000259|Pfam:PF11261"
FT REGION 306..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 93177 MW; DC65F0D597083F46 CRC64;
MVTSTEVAYF SYIYSIIPPE RYQRATGYVR SAMLTGYTFG ATLGQLLISL ADTSYYHVNT
ITLGIMSVAF CVSLGLPMPQ HGMFFKKVEV SADTLNEVTN AFGGEMDLGK QATGTCCNWG
NIKTSGKQMW ESLKESYSSR RLVQWSLWWA LATAGYGQVF NYIQLMWDHI EPSSTASVYN
GGVEAVCALV GAAAAFSVGY IKVQWDMWGE LSLGVFSAVG AGCVFLMGLT NNIWLCYAGY
AIFKASYMFL ITITMRQWCY LCDLPKMPWA MIWDFSEAVC RGCVNYEGAD RIELLIDTAR
QLKRTHVMQD GRSPGPQPSG KHGPAGKEGP MEAGRPPSER YERGRGEYVS ARLPNGLPRL
EDGGPPEVSR QSPTARRTLV GAVPPNLMAQ GLVGAPHGLL TAMPGLNARA GGAPLTISAP
MLNELSKRQA ISMGMNVGVA SFMSPEFEKE LKEKQRNSEA LAELSESVRN RAEDWAGRPK
NMRETLHALS GCTPFNVRFK KDHSVVGRVF AFDAKLMVEF ELKVFVEYPC GSGNVFSSVL
ALVKQMFHDS QKDSGKVINS GYKYVEYEKR HGTGDWRLLS ELLSDGVRAF KDAPAPESLP
QPYLDPSCSM LPSALCHIGR PTQPRVRRRK ASPEPDGAER MISEEMRQHW PLGAYPGLPG
HMPATSLASA GQPPEGMGAH GSDPSPISAL MSVADNVGTA TQSPKDAPGA SGGHSANAVR
QNSASPSPAG GRRLASRNGE PSVGSSAVGP TTTVTVPLVD QGAVMGGEGS GGAGGTGGAP
LCCTICHERL EDTHFVQCPS VPGHKFCFPC TRDFICRQGS GNEVYCPSGE KCPLVGSNVP
WAFMQGEIST ILAGDVKVKK ERDP
//
