ID A0A498MNZ3_LABRO Unreviewed; 777 AA.
AC A0A498MNZ3;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=ROHU_023410 {ECO:0000313|EMBL:RXN22561.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN22561.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN22561.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN22561.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN22561.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN22561.1}.
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DR EMBL; QBIY01012586; RXN22561.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MNZ3; -.
DR STRING; 84645.A0A498MNZ3; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF14; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 18..195
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 561..725
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 757..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 86490 MW; F2F2195989B398BF CRC64;
MPFAVRQAVS AELDSLLQKG IIEKIDSSPW ISPIVVTAKK GGKIRLCVDL REPNKALIVD
SHPLPHMEEL LNDLRGASVF TTIDLMSAYH QLPLHEECRD ITAFITHNGL FRYCWVPYGL
ASALSAFQKM METVLKGIHG VRNYLDDIIV YGATQDSHDA TLRSVMQRLS DAGLELNWEK
CTFSQSSLKF LGHVISKSGI FPDDEHMSAI IDAPAPHDLA SLCSFLGLIS WYSKFLPNFA
SVAEPLRALL RDTSNAEFDW TDSADCSFKA LKELLSTSPV LALFDPSLPI IVSTDASDYG
LGGVLTQMHP DETEKTVAFA SRTLTAAERK YSTVEKEALA CVWAVEKWRP YLWGQHFTLR
TDHHALTTLL ATKGIGRAGM RVAQWSARLL CYTYDVLYRP GSLNCAADCL SRLPLPTKSD
GGLDPEMVAF VTGLPTLSVE NFLSASESCP ELAMLRSQIS QGWPKTSRDL DPVLVPFFCI
RDELCVDGVL VRRGENRAIV PSALRSQLVN LAHETHQGIV QTKRRLRDLF WWPQMDAQVQ
SAVSSCLTCQ MNDKSAKTAP APLQPVSLPP DPWQKLGIYI VGPFDSGPSD CRFAISLIDY
HSKWPEVAFA PNVTAEVVTS FLHSVFSREG NPQCVVTDNG PQFVSSVFAD FLKERGISHI
RSSVYYPQGN AAVERWNRVL KECILSAEQM GKPWKHAVTE FLQKYRATPH STTGVSPSEL
LHHRKMRTKL NIFPVGPKSD KCARVMDTVS NKQLKSKTYT DKRRGAKYPT FKPGDRV
//
