ID A0A498MP16_LABRO Unreviewed; 689 AA.
AC A0A498MP16;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Progestin and adipoQ receptor family member 3-like protein {ECO:0000313|EMBL:RXN21382.1};
GN ORFNames=ROHU_024303 {ECO:0000313|EMBL:RXN21382.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN21382.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN21382.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN21382.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN21382.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ADIPOR family.
CC {ECO:0000256|ARBA:ARBA00007018}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN21382.1}.
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DR EMBL; QBIY01012613; RXN21382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MP16; -.
DR STRING; 84645.A0A498MP16; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF03006; HlyIII; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR604254-1};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:RXN21382.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|PIRSR:PIRSR604254-1}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..689
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019747020"
FT TRANSMEM 215..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..543
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..183
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT BINDING 504
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
FT BINDING 652
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
FT BINDING 656
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PIRSR:PIRSR604254-1"
SQ SEQUENCE 689 AA; 78233 MW; F60A267AE453B174 CRC64;
MRGDSDHASK ATWVLQLFCI SLLTSFGKGD DESCHGAFDL YFVLDRSGSV SDNWMEIYGF
VEQLTNRFVS PKMRVSFIVF SSSAEVVLPL TGDRAAIDNG LQSLNKIIPA GDTYMHEGLK
KADQARHYGA RVYCVGVKDF DANQLKDIAD SKDQVFPVVD GFQALKNIVN SILKKSCIEI
FNLEPSSICV NDEKPSAVKD NYVLCPAPVL TESDGIVIVI VILVLLVLLG LLVLWWFWPL
CCTVVIRDPP PSRPPPPCPI PEPEEDPLPK KKWPTVDASY YGGRGPGGIT RMEVRWGEKG
STEEGARLAK AKNAVVKMPE EEFEEPIKRP PPRPPPIYQA PAPDKWYTPI KGRFDALLAL
LRRQYDRVAI MRPTTNDKMP QNILKSTHYI ELGSYQYWPV LVPRGIRLYT YEQIPVFLKE
NPYITDGYRA HLPSKLCLKS IFILSNETVN IWSHLLGFLL FFSLGVNDMA TVLPSAGASR
EDYVIYSIGL FCFQVCMLCS VGYHLFCCHR SEKTCRRWLA LDYAGISVGI LGCYVPGVFY
AFYCNSFWRQ VYLLTVLAFI LAVFAAQIHP LYLTQQWKKL RSVMFCSVAG YGIIPACHWV
WLNGGFDSEI VKVFFPRVMI MYLIAASAFL FYVSKIPERY FPGQLNYLGA SHQLWHVLVV
VMFYWWHQTA LYIMKYRHNQ PCTEYSSHG
//
