ID A0A498MPN1_LABRO Unreviewed; 510 AA.
AC A0A498MPN1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Bone morphogenetic protein 3 {ECO:0000256|ARBA:ARBA00013361};
GN ORFNames=ROHU_022905 {ECO:0000313|EMBL:RXN23499.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN23499.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN23499.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN23499.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN23499.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN23499.1}.
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DR EMBL; QBIY01012561; RXN23499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MPN1; -.
DR STRING; 84645.A0A498MPN1; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR CDD; cd19393; TGF_beta_BMP3; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF144; BONE MORPHOGENETIC PROTEIN 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 340..452
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 301..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 350..417
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 379..449
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 383..451
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 416
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 510 AA; 58456 MW; ABCA23D85ADE952E CRC64;
MDRCQRLFIL LLGWGYLCCG YCAVLKTPFT GFSKDMQFGQ KVEAQDEQHA KKTEQDTLSE
HMQMLYAKYT SAGFPLKDGN TVRSFKGHLG TINDKQLQIF NLTSLTKSED VLSATLHYYI
GDLQNSSHRC TRHKSCTHHN LRRQGHVHLD IWSFSFVDNT TRTVGHFSIN ISTMYRDFIS
WQWKDITRVV NQAKQHGQLL IGVDIDSKGR QPWKKLLSDR SPYILVYAND SAISEPESVV
STLQRHKSRL VPNLHMLEIH NRSASSQHRT KRSANILLPL QNNELPGPEY NYEVPTWDET
SPYDPVESKP VKRPRKKPRK NPRHKNPLLQ FDEQTIKKAR KKQWNEPKNC ARRYLKVDFA
DIGWSEWIIS PKSFDAYYCS GSCQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE
KMSSLSILFF DEDKNVVLKV YPNMTVDSCA CRCANRSASR PLRLTFETSS VAFTVTGGYY
LQELKYMTSS AILKQGTSHL PAKPRSFLHF
//
