ID A0A498MQR9_LABRO Unreviewed; 688 AA.
AC A0A498MQR9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Cysteine-rich with EGF-like domain 1 {ECO:0000313|EMBL:RXN23121.1};
GN ORFNames=ROHU_006518 {ECO:0000313|EMBL:RXN23121.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN23121.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN23121.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN23121.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN23121.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN23121.1}.
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DR EMBL; QBIY01012568; RXN23121.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498MQR9; -.
DR STRING; 84645.A0A498MQR9; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 3.40.50.11530; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR039465; IL-17_rcpt-like.
DR InterPro; IPR013568; SEFIR_dom.
DR PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR PANTHER; PTHR15583:SF12; INTERLEUKIN-17 RECEPTOR C; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF08357; SEFIR; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51534; SEFIR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 266..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 309..465
FT /note="SEFIR"
FT /evidence="ECO:0000259|PROSITE:PS51534"
FT DOMAIN 569..610
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 20..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77108 MW; 6A4226CF30E08EA8 CRC64;
MDCEPCLWIA IQLSIIPDLK DDEERDTEKS EHEEESSANW DSGCISVSDD TSEVRREDYS
VCEDQQDKAT ITICYHAAEG QQVRCKRLDF TVTSAHKLLS LTLVEYKDVD FGRTMKITVG
SFAKSPAVEI NEFPTLKTGP RVYIKIEEGW VKVLLADEGE RASEGLSLCM KRGREGRCWD
LSNNSIPLAS VTYCTCFQVW KNDSVRVEIC PFENNKTELQ DNVLNNMSVS LAHIKANNGI
REVREYQLKV DEKIVQYCQH PVERQYWSLL VLLPLVLVCL TAFAVLLLVN KLKWPLSKWD
RRCNSQDMRG QVLLLHSSST DPHLVCKLGH LLSELGFGVF LDLWSQTELG SRGPAAWLHS
KLDHIQKHGG KALLVLSPST LERAELYWKI AVEKQNKPAT YSSDTLASAL GCIFADRQKG
CPAQRFVLLQ LDFHELPINE EHDMPKLLRG LPLYKLPSQS QGLLMELCLE SPNNMSGKLK
KMWWIKNAQR KLSQGVQNIF HFCTLTLTDT DECGTDLDQC PDNTYCFNTH GSYECKECDK
ACVGCMGGGS ARCRKCAAGY RSSGMRCIDI DECAEEVLAC PGVNVFCVNT EGSFHCQCAV
GYTPRGDACE RSQTAASEEK GLFDDIQEDE IEVLQQMFFG VVLCALATLA AKGDLVFTSI
FMGAMAAMAG YWLSDKSDRV IDSILKGR
//
