ID A0A498MSL5_LABRO Unreviewed; 4517 AA.
AC A0A498MSL5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Dynein heavy chain axonemal-like protein {ECO:0000313|EMBL:RXN24689.1};
GN ORFNames=ROHU_022101 {ECO:0000313|EMBL:RXN24689.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN24689.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN24689.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN24689.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN24689.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN24689.1}.
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DR EMBL; QBIY01012521; RXN24689.1; -; Genomic_DNA.
DR STRING; 84645.A0A498MSL5; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498MSL5};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2038..2174
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2317..2472
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2612..2760
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3231..3311
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3458..3513
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4517 AA; 513776 MW; 9CAFE3C46FAC47AA CRC64;
MASSASVTIA TINFASGFQF VLTDLTSLGQ DANGTEKETA VPGSEVPGVP LEDKQGFREE
STISTYENDD IANPLLSSLS DLEVKPPLTT IKTGVGKHRR IGVQKEKTIN QTIPAAIPQA
VSTAVSGKRS VILSNEARKE KIKQVKALKD ERRAALDGRH KYLISIIAEV ISLGDAEVEE
AIISDDKFYM IEEFFSASGS KSLTFFYQVT ETSHSWIDTT NLASGQKKLF ITTGTNEGLT
GQCLFFMRIT DKAITTTNIS QEVNFGMLDC SETSVLHSLE FLFTQVMNQA LKSQEDWGAI
KGGQMSPDVQ DFLRSVDKFT CTLSSVMRNM EEKFRLQNIP SAPDLSHIQK ADDYSNAANN
SELVESLEAV LLHWAKQIEQ VLTESERIRR ESDDIGPSAE LAHWKRRMIT FSSLLDEIKD
PYVKMVVGIL NAAKSKTLSK WKELDANITV VANEAKDNVK YLSTLDKFFE LLEKSSPTTM
LCQIPKLMNS IHMIQRVSQY YNTSEHMTSL FVKVTNQMVT TCKAYLCQGV TKIWDLDRKE
LLKRMKECIQ LNQEYQQCFH RMKEILQENP LERQFELSEN YIFGKFDTFC KRLEKITDMA
TTLEDFSSLQ FMKVEGVEKI YMRYQTIVTG IKSKTYNVLD HRKLEFENDY IEFRRQIQGL
YQSLDALIDT WLQRPLITHQ IIDLLSKFET SVGRQMDLTQ KYMLVLQRYE SDLEFVRKLY
QREKNNPSSA QFKTPLASKI QWSQNLFKKI HLPMQILKEK LDIMQIPERR KIIQAYNKLA
AVLLEYEMIH HKAWVDGVDL GLYGLKASLL TRHPETKVFY VNLDPLVLEV LQEAKNMYAL
GANVPDVIHN MAAKEPQLKE YRTKLQEMLS NFDAVVKRIP SVLQSPMKPF IRSVENALYP
GLTSLSWTSL NIDYFIGHVY KPLQELEQVV RVAVDILECR IERTLESIAS TNLLTLPKNQ
PVTPEMFLTN TETTVNAARH TLKIASNQVE SSMLEMVEEL KTVLKPSERV NLKDYKCLHP
DAKQKTRCLY CLPCAFYIMM GQLCQRNTEA LVRATKRSLD SLRRRLLVVS SKYRSSSQSE
ATVQFPLFKV SVELAIPSII FRPSFEQIQG ILNKAVNMVL SMAKDIPLWQ YSHVQQEQLE
VEQAAARELG DEALVTKPLV LRTLDRQVTE HKDVNKALSQ LVPVVSSLKA DAGDILKGLS
QFSDLWKQDP AEQVKAFLET KPLLSEFSAK LSLYSTYETR IQELPSTCTV CPILYETDSL
KLSLIQECRT WKRAFGAALN QKASVGMAEI SSFVDGVSKQ LQRPISDLDD VRETMAALQE
IREAEIRIET TRGPVEESFA LLNRHELFFS DGNAEKIDGV VYAWKELNVM AKETQNKLLE
IQPQMKAELV AGVEVFQQSV QTFYADYDNS GPGVAGLAPR EASDRLQIYQ ARFDELWRKF
VTFSSGEELF GLPVTGASVF PTLLVIKREL NLLSKLYSLY NSVIDSVSGY YDILWADLNI
EKINSELLDF QNRIRKLPGA LKEWQAFNDL KKTIDDFNET CPLLYMMANK AMMSRHWQRL
TDLTGHKFEV EAANFSLRNI MEAPLLKNKE DIEDVCISAV KERDIEAKLK DVVTEWSSHQ
FTFASFRNRG ELLLKGSDTS EKVALMEDSL MVLGSLMSNR YNAPFKPTIQ QWVQKLSNSS
EVIEKWLTVQ NLWLYLEAVF VGGDIAKQLP QEAKRFQTID KSWQRIMQRA HEIPGVVQCC
VGDETLQQLL PHLLEQLEVC QKSLSGYLEK KRLVFPRFFF VSDPVLLEIL GQASDSHTIQ
VHLLNLFDNV NRVVFNEKNY DQILSFQSQE GETVNLSEPI NAQGNVEAWL GLLLDGVKKT
IHNIIRQAHM VISDQGFKLV EFQSMFPAQV GLLGIQLIWT RDAEEALCNS RTDKKIMQTT
NQKFLDLLNE LIDMTTHDLT KMERTKYETL ITIHVHQKDI FDDLVRMNIR SPLDFEWQKQ
SRFYFKEDMD RCIIQITDVE FDYCNEYLGC TDRLVITPLT DRQVCYITLA QALGMSMGGA
PAGPAGTGKT ETTKDMGRCL GKYVVVFNCS DQMDFRGLGR IYKGLAQSGA WGCFDEFNRI
ELPVLSVAAQ QIYIVLQCKK NKKTQFIFTD GDVVDMDREF GIFLTMNPGY AGRQELPENL
KIQFRTVAMM VPDRAIIMRV KLASAGFREN QVLSRKFYTL YKLCEEQLSK QVHYDFGLRN
ILSVLRTLGA VKRSNPAEPE KTVVMRVLRD MNLSKLVDED EPLFMSLIND LFPGIQLDKA
GYPDLEAAIT KQAEEAGLIA HPPWILKLVQ LYETQRVRHG MMTLGPSGTG KTTCIHTLMK
AMTDCGNPHK EMRMNPKAIT ASQMFGTLDV ATNDWTDGVF STLWRKTLKA KKGEHIWIVL
DGPVDAIWIE NLNSVLDDNK TLTLANGDRI PMAPNCKVVF EPHNIDNASP ATVSRNGMVF
MSSSVLDWQP ILQAWLQKIP ATQAEVLLAS FNSVYQGLLP AVEEKHLTAA HIKRLFIFAV
MWSVGALLEL DDRAKMEVYL KQHNAKLDLP KTQGDQTIFE FVVSATGEWD LWSTRVPEYH
YPKDTVPDYA SILVPNVDNI RTDFLMQTVM KQGKAVLLIG EQGTAKTVMI KGYMSKYDPE
THLSKSLNFS SATLPGMFQQ TIESYIDKRM GTTYGPPGGK KMTVFIDDIN MPVINEWGDQ
ITNEIVRQLM VQGGFYSLER SGEFTTVVDL QLVAAMIHPG GGRNDIPQRL KRQFCVFNCT
LPSNSSIDKI FLTLASGYFC SEREFPEEVC SLAAALVPTT RRVWQAVKAK MLPSPAKFHY
IFNLRDLSRI WQGILTVGSE VCKTPQLLAS LFRHECTRVI ADRFIDQKDR ETFDGILERI
TVQDHGPALV EQGPTETYFV DFLRDAPEMT GDEPEDAEAE TPKIYEPIPS FKALSDRLSV
FQQQYNETVR GAAMDLVFFE DAMIHLMKIS RIIRTARGNA LLVGVGGSGK QSLTRLSSFI
AGYQSFQITL TRTYNVSNLI EDLKTLYRIA GLEGKGVTFI FTDNDIKDEA FLEYMNNVLA
SGEVSNLFAR DEVDEITQSL IPVMKKDLPR CPPTIDNLYN YFLSRVRSNL HVALCFSPVG
EKLRSRALKF PGLISGCTVD WFQRWPRDAL VAVAQHFLSN YSLRCSNEVK KSVVETMGTF
QDMVAEICTE YFQRFRRQTY VTPKSYLTFI KGYQMIYSEK IEHVGMLAER MNTGLERLME
AEQSVNELRV ELREKEKVLA VANQKAGEVL QEVTAKAQAA EKVKAQVQKV KDKAQAIVDE
IEGDKKVAES KLEAAKPALE AAEAALKTIK PADIATVRKL GKPPHLIMRI MDCVLLLFQR
RVDVVTMDPE RPCVKPSWSE ALKLMNNAGF LGMLLNFNKD TITEEMVELL SPYLSMEDYN
LETAKRTCGN VAGLCSWTEA MVEFFGINKE VLPLKANLKL QEARLTVAQE ELSKAQEQLD
AKQKELDEAQ TMYDAAMKEK QDLLDDAEAC KKKMSNAVAL IDGLGGEKIR WTESSAQFER
QIKDLVGDVL LATGFLSYSG PFNQEYRSLL LQQWKKEMNI RRIPYSENLN LISMLVDNAT
IGEWNLQGLP NDDLSIQNGI IEMEAERVKL LEEVTSNKRK MQELESNLLY KLTSIQGSLV
EDESLIEVLG VTKTIAQEVS QKLAVAAETE MNINNTREEY RPVATRGSIL YFLIVEMSLV
NVMYQTSLRQ FLGIFDMSME KSPKSHVTAK RLDNIMEYLT FEVFRYTARG LYEDHKFLFT
LLLTLKIDLQ AKNVSHSEFQ TFIKGGASLD LNSVEPKPRR WILDTTWLNL VQLSSLPPFS
ALLTQVARND RAWKSWFDEA TPEETPLPDG YESQLDAFRK LLLIRSWCPD RTIAQARKYI
AESMGLKYAE GVILDMDAMC SESDKRIPLV CFLSMGSDPT ENIERLAKSK GVPCRPISMG
QGQEIHARRL LAQSMSDGGW LLLQNCHLGL EFLDEGLDTV TTTESIHDSF RLWVTTEVHP
KFPINFLQSS IKFTNEPPQG VKAGLKRTYN SVTQEQLEIS NMPQWRPLFY AVAFLHTTVQ
ERRKFGPLGW NIPYEFNQAD FTSSVQFVQN HLDDMDAKRG VNWTCLRYML GEVQYGGRVT
DDMDKRLLNT FARIWFSENM FGDKFCFYKG YTIPNVKMLQ DYHAHIDTLP LVDTPEVFGL
HPNADITYQT NMANETLSTI LNIQPKDSSS GEGETRESAV QRMANEMLEK LPPDYVPHEV
RSNLQKMGAF QPMTIFLRQE LDRMQRVIGR VRSTLTDLKL AIDGTIIMSE DLRDALDSMY
DARVPKSWQK ISWDAASLGF WFTELLERNQ QFHNWTFSGR PHQFWLTGFF NPQGFLTAMR
QETTRMNLSK GWALDTVILL NDVTRMMKED VTGPPPGDVG GVYIYGLYLD GAGWDKKNAK
LTESSPKVLF TPLPVVHVYA VSSTTETKKP PMNLYSCPVY KKPRRTDLTY IFPLLLRSSQ
NPDHWTLRGV ALLCDCK
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