ID   A0A498MUG6_LABRO        Unreviewed;       545 AA.
AC   A0A498MUG6;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Mitofusin-1 isoform X1 {ECO:0000313|EMBL:RXN23342.1};
GN   ORFNames=ROHU_022748 {ECO:0000313|EMBL:RXN23342.1};
OS   Labeo rohita (Indian major carp) (Cyprinus rohita).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Labeoninae; Labeonini; Labeo.
OX   NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN23342.1, ECO:0000313|Proteomes:UP000290572};
RN   [1] {ECO:0000313|EMBL:RXN23342.1, ECO:0000313|Proteomes:UP000290572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN23342.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:RXN23342.1};
RA   Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA   Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA   Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA   Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA   Shah T.M., Rai A., Jena J.K.;
RT   "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004374}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXN23342.1}.
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DR   EMBL; QBIY01012561; RXN23342.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498MUG6; -.
DR   STRING; 84645.A0A498MUG6; -.
DR   Proteomes; UP000290572; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR006884; Fzo/mitofusin_HR2.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465:SF2; MITOFUSIN-1; 1.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF04799; Fzo_mitofusin; 1.
DR   SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          73..317
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   COILED          338..365
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   545 AA;  61915 MW;  99D2A060DFFD6926 CRC64;
     MELDNVSPLQ HFVVAKRTIS AVFHQLLEFV RECSDFVEET WKNEDLEHVA EEKQCLQIQA
     CSRKLTVIKD VLARRHMKVA FFGRTSNGKS TVINAMLRER VLPSGIGHTT NCFLSVEGTD
     GEHAYLTTDD SEERKNIETV NQLAHALHMD RNQDSGCLVR VFWPKAKCAL LRDDLVLMDS
     PGTDVTSELD SWIDKFCLDA DVFVLVANSE STIMNTVRKQ HMDRCVSFLV EELKVVDLNK
     APDRIFFVSA KEVLSARIHR AQGMPETGGA LAEGFQERLM EFQSFERTFE EFISQSAVKT
     KFEQHTIRAW QITESVKAIM DAINISSAEK KVFSLEEREA LMDRLEFVRN QLNFLTEDIK
     DKIKAITDKV ADKLSSSSAP LGAQEELAIS MATGLVSLTS RASVGMLVIA GVVWRSAGWR
     VIVLSVSLYS LLYLYERLTW TNSAKERALK QQFVDYATQR LQAISHIISS DCGQQVQQEM
     VAVFARMCQQ VDKSEMELET EIRTLSARIQ RLECVQRHSK TLRHKATDLE SQLESFSAQY
     LQIQH
//