ID A0A498MVL7_LABRO Unreviewed; 2556 AA.
AC A0A498MVL7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 05-FEB-2025, entry version 19.
DE SubName: Full=Centromere F {ECO:0000313|EMBL:RXN20675.1};
GN ORFNames=ROHU_024767 {ECO:0000313|EMBL:RXN20675.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN20675.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN20675.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN20675.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN20675.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN20675.1}.
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DR EMBL; QBIY01012633; RXN20675.1; -; Genomic_DNA.
DR STRING; 84645.A0A498MVL7; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0000922; C:spindle pole; IEA:TreeGrafter.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0051310; P:metaphase chromosome alignment; IEA:TreeGrafter.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:TreeGrafter.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:TreeGrafter.
DR Gene3D; 1.10.287.1490; -; 3.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR InterPro; IPR025925; PPC89_CLD.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
DR Pfam; PF14197; Cep57_CLD_2; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 106..258
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1659..1799
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 1897..1997
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2211..2274
FT /note="PPC89 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14197"
FT DOMAIN 2415..2455
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 155..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2504..2556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 725..822
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 847..930
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 983..1231
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1270..1332
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1418..1489
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1551..1634
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1670..1711
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1754..1837
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1873..2079
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 158..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1525..1536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2355..2372
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2461..2481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2504..2516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2556 AA; 292613 MW; 7A5623B4748628C6 CRC64;
MGSIFAETNV YMLHMMYQAM GVCLYMQDWD GAMKYGEKII QPYSVHYPPY SLNVASMYLK
LGRLYLGLEK KTQGVKALKK ALAVMDIAHE HARVSLRSNT AFSVNMSWAV EEWKDGLPAK
ALQKIQEIEA QLDKLKKERQ QKQFQLDSLE ATLQKQRQKM DSEKSEASAL KRENQSLVES
CEGLEKTRQK LTHDIQTKEQ QVNYLEGQLN SSKKQIDRLE QEIKKYKHDL ERSQTSHASE
IQQFTTPQKT FATPATPNHW QQDLRSKISE LELRIQAQEK EMKNQINKFS EIQSQLEMAK
KDLAEKDKLL SKSRDELTKA TGQYEQSVSK CSSLEMKLKQ ELAQLQSSHQ ALDQQFNQVK
NKMSMEIQQA KKDHNVLQSD MDKVTALKNR LEKDLEELKQ KLLRSEQALQ ASQVKETELK
KKSDEMQREK NSLSCQLDQG MKRVKQLEDE KQNIEQNLAK NRTMVDDLKV KTQTQSEELT
ELRKKMDRQS ASSAQELENA KKTLAEIEAK NTKTQAELQK LVHEVELKAS KICAMEKENE
DLKMTSNSCQ KEVAEIKKEY EALLQWKTEK EQLINNTESN REEMLSKIAD LASDKAKLND
AQDGLQKRMQ DLENEKICLS GQIDSLKGEL LVKCVELEEK GRVYEELQQQ FSETHQKHNK
EMDNLKQQIT LMQEQVSELE AKLHQETSKV DGLEKAHGQL LAEYESACDL AKSKDSIIEM
NKTKIEHLQE TFALQEQELE KFKEEKEMLA KECEDHLVQN KELEQEKLNM ETSLQEVLEK
IALLESDLKS QKDSNADIQA KYDDLSKVKE DLAEKVSLVE KREKDLVLEV ESLLQKNKSF
GSLEEQFNSL VSEAEETRSS LEKLKELQVQ TATELGHQKT IAENLVKDIE EERRKASSLE
HDNAQLKVKQ QEVENKINDL AEKYESLQKS HDIVCQEKEN LLTQVSEMTG ALAERDAMAE
TIVLTQTELE ASNHLSTTLK NSLESLQKQF DSSVEQNLSL EKNVQGLSEE KALLETSIKE
LTERHNKETE VHVSEMETHL KKQNSLEEQI SVIEAELQSK CLQARNASEK QEEAALEIVQ
LKQDFDLSKD QLREVTDSYQ KVAKELEDLK QSASPHEQEI ESLKAALADL KSQEAAKTCE
VKTLKEKLKE SQSEQAKVLE TLNEKNIKLS KIEVQLEMLQ MDLEDNETCI NSFDAQVEAL
QGNISVLEAK LGESEAQRSI LQTELESVKE DYAKSALEVS QLSACLEETQ KEQQSSSALV
AELESLRVTH ETLKVSLEQE NCKLANLEAM YNNLMEQKLK LESNIQELKA DAQNSLKQID
QLKQANDSLV SQFAEQQTYI AQLQSEKIPA ANSDADTLKK AQTVDDNDQD ICEMPFANTS
ILPFEEDVAV QGISSPGEHL DSQEETQTSL SSDEDGKHVL LKEQMQNTNR ELEKAIRTME
EQTGVKIEQL KLQHAEELQR MEQQMLCIRN ELEAKLREEK QHTEILSSQL EATMQQLQEL
DLASSSLLAT ETSQEMEKMT HEAQENITHQ PEQSDSAPDI SPESEKSLVE LETLKETLRK
REAELVHLQS QFELLESEMA VRKDLCSDLE GKIREMEGEK TNVTDKLTSG TQENQKMNNH
IGKLTEEIDS LRLQLQTSTC QLSDVMEMIE SLEMAKGEWS EKFFQTESEL KRVRSEKANL
EKHILSMEAD IEEIQEQKQK QAADLEAVRR TNCSLEQQLN MTMAEGGRLK EELILCADER
ESENLSLIKW KEKAELLEKR ESNTRELIKE LEEDIRMGKR QNEATSNQID ALLKEKEQLV
QQSQNLENTV SLLNEDKKNL LSELNSLKNN ENFASRESEN MSSKIHSLEH ENIRLSQSLE
SSLLEKGEIA SRLISTQEEV AQMRQGIEKL KVRIESDERK KNHMSQLLKA AQRKADVLQD
NIERLEREKE LSEQNLEDAV LQAETAKAEL EESLQSENKE FAQRVLEYER CQVELRSSND
LLLKDFENKQ QELSEENARL QSQIAELQAL SSVKEERDEL KKDKAELQSI IAQLEETTQM
QSTKIEVLQT SVASLENNIQ QLESQLDAMK LMNTELTEKL NALHESSLHL QTQHQHELCE
ARERQNALEI NQNLLACQLQ ESQKQIETYK LSLEALTTEK DGLQKNVSDI QESHDVQIKK
NNRRHEENLK HVQQQHEMER NGLKEEIKAV EEKAAQYLSD LNSFKSQNAD VDSTLKELQN
KLEHFEKEKA ELDSKIVRLS KEKDSAMSKI NLWMKSCKQL ETEKQALQEE LQQQGQALTD
SQKQGDAENG DALQEELQEL KEALEEKSRE ADESMDRYCS LMVKVHKLEE TNESLKNQLK
QLSIQTKTPK TRRSLRSEKS DLENSKPVED KANVPGGKRP RAVDDTPNKA QEALHSITKR
LKAAATTPKA TLDVDDEDFR PEGLPELVQK GFADIPLGEM SPFIIRRTTV QRCSPRLAAQ
KTATQQSSVS TEHPVQISRQ TAEGRKSYPV QAPKAIQSNA AVLSPLTNSP QKNSCESLLP
ASAQKISRRS RSFKKSPEKQ ERVCASPKEN DNCQVQ
//
