ID A0A498MW06_LABRO Unreviewed; 2770 AA.
AC A0A498MW06;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Fibrillin-2-like protein {ECO:0000313|EMBL:RXN20795.1};
GN ORFNames=ROHU_007003 {ECO:0000313|EMBL:RXN20795.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN20795.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN20795.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN20795.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN20795.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN20795.1}.
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DR EMBL; QBIY01012631; RXN20795.1; -; Genomic_DNA.
DR STRING; 84645.A0A498MW06; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 27.
DR Gene3D; 2.10.25.10; Laminin; 44.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24040:SF13; FIBROPELLIN-1; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 35.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 4.
DR SMART; SM00181; EGF; 43.
DR SMART; SM00179; EGF_CA; 43.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 39.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 26.
DR PROSITE; PS50026; EGF_3; 39.
DR PROSITE; PS01187; EGF_CA; 18.
DR PROSITE; PS51364; TB; 9.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498MW06};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..2770
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019792912"
FT DOMAIN 123..166
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 185..226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 227..268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 273..326
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 395..433
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 436..475
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 476..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 518..558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 559..599
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 605..657
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 669..710
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 753..788
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 797..836
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 856..897
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 902..953
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 974..1015
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1016..1058
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1059..1100
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1101..1142
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1172..1213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1214..1251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1256..1296
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1297..1337
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1338..1379
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1380..1416
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1421..1461
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1466..1522
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1539..1580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1581..1618
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1627..1679
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1697..1738
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1739..1777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1781..1822
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1823..1858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1862..1901
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1902..1943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1948..2001
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2016..2057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2058..2097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2139..2179
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2200..2241
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2246..2299
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2311..2352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2353..2393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2394..2430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2433..2475
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2516..2552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 440..450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 757..767
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1827..1837
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2770 AA; 299826 MW; 68484A305B7ECBFC CRC64;
MGVWKLAKVV LGWAAIWWAA VHSAQAQGDG DIQASRFTGK PEGEVQQRVR RRGQESLRGP
NVCGSRFHSY CCPGWKTLPG GNQCIVLQSC SVRCMNGGVC NEDACSCQKG YTGTHCGQHY
RTGPCFTQVN NQMCQGQLSG IVCTKTLCCA TIGRAWGHPC EMCPAQPHPC RRGFIPNIRT
GACQDVDECQ AVPGLCAGGN CINTVGSYEC KCPAGHRQSE TNQKCEDIDE CATISGVCDG
GECTNTAGSY VCTCPRGYIT SADGSRCVDH RVGTCFSSLA NGRCASELSG QYTKMQCCCD
TGRCWALGHI PEMCPVRGSD EYRRLCIQRL PFATGNGGGI IHDGNGGLNI GSYGKGPSQN
GNGGGYIYGG EHGIGNGNGG NGGPKIQISQ LNETTIDVCK HFTNLCLNGR CIPTPTSYRC
ECNMGYRQDV RGECIDVDEC ISNPCVNGDC VNTQGSYHCK CHEGYQGTPT KQACIDIDEC
IVNGVMCRNG RCVNTDGSFQ CICNAGFEIS PDGKNCVDHD ECATTNMCLN GMCINEDGSF
KCICKPGFAL APNGRYCTDI DECQTSGICM NGRCVNTEGS FRCECPPGLA IDVDGRVCVD
THMRTTCYGA IKMGTCSRPF PRAVTKSECC CANPEHGFGE PCQPCPAFNS AEFQAVCSSG
PGITADGRDI NECALDPDIC QNGICENLRG SYRCICNIGY ESDASGKNCV DINECLVNRL
LCDNGMCRNT PGSYTCTCPK GFSFKADSET CEDVNECDSN PCINGVCRNI AGSFSCECSH
GSKLDSTNTI CVDSMKGTCW LNIQDGRCEV NINGATLKSE CCSTLGAAWG SPCERCEIDP
ACSKGFARKK GLVCEDINEC EVFPGICTNG RCVNTQGSFR CECPEGLTLD GAGRTCVDIR
SEQCYMKWDE DECVEPLPGR YRVDMCCCTV GAAWGVDCEA CPKPNTPEFK TICPRGPGIA
NRGDILTGRP FYKDVNECKV FKGLCTHGTC RNTIGSFKCR CDSGFALTME ERNCTDIDEC
TISPDLCGHG VCVNTPGSFE CECFDGYESG FMMMKNCMDI DECERDPLLC RGGTCLNTEG
SYECDCPPGH QLSTEASACE DVNECELSDN LCRNGHCVNM VGTYQCSCDT GYQVTPDRQG
CVDIDECTIM NGGCDTHCTN SEGSYECSCS EDIDECEDTP DICDGGQCTN IPGEYRCLCY
DGFMASMDMR TCIDVNECDL NPNICLHGDC ENTKGSFICH CQLGYFVKKG STGCTDIDEC
EIGAHNCDMH AACVNVPGSF KCRCRDGWEG DGIKCVDVDE CLTEEHNCNP NAECMNTPGS
YRCSCKEGFN GDGFTCSDMD ECADNVNLCE NGQCLNAPGG YRCECEMGFT PTEDSKACQD
IDECNFQNIC VFGSCQNLPG MFRCVCDYGY ELDRSGGNCT DINECFDPVN CINGVCVNLP
GSYLCNCPPD FELNPSGVGC VDTRVGNCFL DTLDRGDGGI SCSAEIGVGV TRASCCCSLG
GAWGNPCELC PAINSTEYKT LCPGGEGFRP NPITVILEDI DECQELPGLC QGGNCVNTFG
SFQCECPAGY YLNEETRICE DIDECTAHIG ICGPGTCYNT LGNYTCVCPP EYMQVNGGNN
CMDMRKSVCY RNFNDTCENE LSFNMTKKMC CCAYNVGKAW NRPCEACPTP ATSEYQLLCG
NQAPGFIIDI LTGKPIDIDE CREITGICAN GVCINQIGSF RCECPMGFSY NNILLICEDI
DECNSGDNLC QRNANCINIP GSYRCECSAG FKLSPSGACV DRNECQEIPN VCSHGECIDT
QGSFRCLCHN GFKTTPDQTM CMDIDECDRQ PCGNGTCKNT VGSYNCLCFP GFELTHNNDC
MDINECVTLP GACQPGTCQN LDGSFRCICP PGYEVQNDKC VDINECNVEP NICQFGTCKN
TPGSFQCICQ PGFVLSDNGR RCFDTRESFC FTRFEAGKCS VPKPLNTTKA KCCCSLLPGE
GWGDPCELCP RETEAAFHTL CPYGHEAVPR PEGREDMNEC VENPGICGNG LCINTDGSFR
CECPFGYNLD YTGVNCVDTD ECSIGNPCGN GTCSNVPGGF ECSCQEGFEP GPMMTCEDIN
ECAVNPLLCA FRCVNTFGSY ECMCPTGYVL RDDNRMCRDQ DECAEGLDDC ASRGMACKNQ
IGTFMCICPP GMTRRPDGEG CMVVSYHLFL SRPLRVTLAD LNECRSKPGI CKNGRCVNTV
GSYRCECNEG FEPSSTGTEC IDNRKGFCFT EVLQTMCQQS STNRNTVTKS ECCCNGGRGW
GSLCELCPLP GTVQYKKMCP LGPGYTTDGR DINECEVMPN LCKNGQCINS VGSFRCHCNV
GYTNDFTGTS CIDMDECSQS PKPCNFLCKN TEGSYLCSCP RGYILQPDGK TCKDLDECST
KQHNCQFLCV NTIGGFTCKC PSGFTQHQTA CIDNNECSNQ PNVCGSRASC LNTPGSFNCE
CQKGFSLDAT GINCDDVDEC GGNHRCQHGC QNMLGGYRCG CPQGYVQHYQ WNQCVDENEC
AGNQVCGSAS CYNTLGSYKC VCPSGFDFEA SAGGCQDVNE CALNNNPCSY GCSNTDGGYL
CGCPGGFYRA GQGHCITGAG FPGQFASEGV DDEEALSPEA CYECKINGDL GKKGRHRRNA
GDNELKETVS MASMDVQTSI PMNLSLAQLQ NKEPLLELLP ALEPLEHHVR YVITHGNQGE
HFRILERRDG KSVLRLGRKP PPPGLYRLEI ASLRLFGPRK LQQMEDQHDS DYLLGEIGDA
LRIKLHIHLH
//