ID   A0A498MWX1_LABRO        Unreviewed;       985 AA.
AC   A0A498MWX1;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Voltage-dependent calcium channel subunit alpha-2 delta-2-like protein {ECO:0000313|EMBL:RXN22716.1};
GN   ORFNames=ROHU_006642 {ECO:0000313|EMBL:RXN22716.1};
OS   Labeo rohita (Indian major carp) (Cyprinus rohita).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Labeoninae; Labeonini; Labeo.
OX   NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN22716.1, ECO:0000313|Proteomes:UP000290572};
RN   [1] {ECO:0000313|EMBL:RXN22716.1, ECO:0000313|Proteomes:UP000290572}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN22716.1};
RC   TISSUE=Testis {ECO:0000313|EMBL:RXN22716.1};
RA   Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA   Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA   Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA   Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA   Shah T.M., Rai A., Jena J.K.;
RT   "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC       family. {ECO:0000256|ARBA:ARBA00007060}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RXN22716.1}.
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DR   EMBL; QBIY01012582; RXN22716.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498MWX1; -.
DR   STRING; 84645.A0A498MWX1; -.
DR   Proteomes; UP000290572; Unassembled WGS sequence.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR   CDD; cd18774; PDC2_HK_sensor; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013680; VDCC_a2/dsu.
DR   InterPro; IPR013608; VWA_N.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10166:SF68; CALCIUM CHANNEL, VOLTAGE-DEPENDENT, ALPHA 2_DELTA SUBUNIT 2 ISOFORM X1; 1.
DR   PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR   Pfam; PF08473; VGCC_alpha2; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   Pfam; PF08399; VWA_N; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022882};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   DOMAIN          244..338
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   COILED          75..106
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   985 AA;  111796 MW;  695EB44F64AEB917 CRC64;
     MDILLSWITV RICAVDWSVF MENGEMGSRV SADDDGDFQR IVDRSGRAHI STALHFYSEK
     RRQFSLVRNN PRDIVEKVAT DIERLLAKKR KALEKLASEA ERLQKDHRWQ DGIKEENIEY
     YNSKAEMDYD GEDIDSQMSL KLEFVYDPNF KNHVNYSHTA VQIPTDIYKG APVILNELNW
     TQALERVFIE NSRDDPSLLW QAFGSATGVT RYYPAAPWRA PDKIDLYDVR RRPWYIQGAS
     SPKDMVILVD VSGSVSGLTL KLIKASVTEM LDTLSDDDYV NVARFNEKAE AVVPCFKHLV
     QANVRNKKIF KEAVQQMQAK GTTDYKSGFH FAFNQLLNVR VFTFSVGQHN YDVTPLQWIA
     CANKGYYFEI RSICAIRINT QEYLDVLGRP MVLAGRSAKQ VQWTNVYQDA LGLGLVVTGT
     MPVFNLTVDG NSQNQLILGV MGVDVHLDEL KRLTPQYKLG ANGYIFAIDP NGYVLMHPNL
     QPREEDLPEP VTLDFLDAEV EDSSKQERYI DDVTRMYTWT PINDTDYSLG LVLPPYSEYY
     IQADLSDVML QLQYLQSLLP NSFESAGHVF LAPREYCKRL QMAENNTQFL ADFLSLMVEI
     SPESEDCDQG LIHNLILDSG ILWQLASRVW QNKDLNTYGF LALFASTNGG VTRVYPNIAA
     ESWDEDPEPL NSNFYRRTLD NKGYIFRAPT RTSMDDLLIT ENGTVGILVT TAVEVVISGK
     TMRPAVVGVK LDLEAWVDKF KILASNVSDS RQAAHKCGPS RSCEMDCEVN SDDLLCYLID
     DGGFLVMSNQ RDHWKKVGLF FGEVDPYLMF ALYNNSIYAR HQTFQYQSAC EPTASSHTGA
     AHRGFYVPSI ADFLSLAWWT SAAAWSILQQ FLYGLIYSSW FTTEDVWAES SDTKGSSSCV
     TVHSQFYFTN TTNSFNVLQD CGNCSRLFHA KRIENTNLLF VVAETLPCSS SQEENPCEVL
     NSARYRKGPD KCFDYNSEVT CCLLL
//