ID A0A498N4U0_LABRO Unreviewed; 1594 AA.
AC A0A498N4U0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Alsin-like isoform X2 {ECO:0000313|EMBL:RXN28050.1};
GN ORFNames=ROHU_019555 {ECO:0000313|EMBL:RXN28050.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN28050.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN28050.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN28050.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN28050.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN28050.1}.
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DR EMBL; QBIY01011906; RXN28050.1; -; Genomic_DNA.
DR STRING; 84645.A0A498N4U0; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 6.
DR Pfam; PF00415; RCC1; 4.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00698; MORN; 6.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 5.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT REPEAT 59..106
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 107..165
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 166..216
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 536..587
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 588..638
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 675..873
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1450..1594
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 261..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1383..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1594 AA; 176529 MW; 08DD60906313D55C CRC64;
MLMEEQSSSG EEEGSREKGV LYRWQGYFCR VTPERLLLSR PVLHAALGTV HGLLLTEDGH
VYSFGEQPWK QVESQPAGPV IESTLIGQHV ISVSAGSYHC SAVTEDGLIY MWGENSHGQC
GVSGMDQVTS PTPVNVVDGE THPPQLVRVL NVACGAQHTL ALSRKHEVWA WGSGCQLGLV
TNVFPVWEPQ KVEHLVGRYV VQIACGGFHS LALVQILSPP ESSQQAQDKC GQCKQSRYTM
TDKDDHVIIS DEHYCPLGVE LSDSKEGRRS GQSTPAQTPQ SKNSSPPLTS KNICEDPVGS
QQNTTSLEAQ PAPAVSETGH ARLRRTKSTP YPDEQALKDY LKRISDQTLA EQAEAASLGG
SHPPSRQSSL KCPFISDQSD ELTLRPSSPA LIRTESLTAS GRQRCASDSV TDRKHSLHLI
PTLDSTSDDS SQHSSVDGGV CISDLVLSNG CLFESSEERG ETAGMDFCPA DPLQGNKSTS
LTDITLEDGE AHNRRGSSSG FSPVSPSGVH RTNYSRAVVG AKTTSESRNL LPSLYTEVWS
WGRGQEGQLG HGDYLPRLQP LCIKSLSKME VVKITAGANH SLALTAQCQV YSWGSDKFGQ
LGRINAPSTV PNLTMISEGI RVWDVAAGQT HTLLLADGDR YQPILYYSGE QIGYVSKVFG
GGLNCLALAD QNAMGFIATI HELASAERKF YCVLSQVKSK ILSPLLARAS LALSLGQSSM
LLFQELAGSF SKLCHLTGQH SVSLTNFLQR GKMIKTLVLI KNTTIFMDTY KEYSDPVGNF
LVMGGFLSLL KPSQECFGKK LELLQSLLES KEKNAAPYDL LVNLFYMPLQ HLHGYNRLLL
KLAHCFEVNT EEYEWIQNGC SKYEDLACFV SKQRRDAEAT FNFWKNFKGK NSESLRKPSR
RLVCESSNKS LTLQNAGRFS ASWFILFSDV LVHAQGKWLR AINQAIEDVL AVGLNGRTRV
SRSSQKGEPP VSRTSSYTFS KEGRLKDATY EGRWLSGKPH GKGTLKWPDG TVYCGTFKNG
LEDGFGDFMM PNTTLNKFER YQGHWKEGKI HGFGTFWYAS GEVYEGSFRD NMRHGHGMLR
SGKLASPSSS SVFVGQWVQG KRTGYGVCDD FSRGEKYMGM WLDDQRHGDG VVITQFGLYY
EGNFCSNKMM SNGTLLCDDD TVFEGEFSED WTLCGKGVLF MPNGDSLDGV FDGHWGAGLR
VAGTFTKPFE ALRIERKIPV AGQHAVPAEE KWKAVFDECW SRLGCETPGE GLHEKAWENI
AIALTARHRQ QRFRPEELSR SQTKMLESLE VIPKHVDPVT ADSYNNIRRY LLKACDTPHH
PLGWLLETLV TVYRMTYVGV GSNRRLLQQA VEEIQSYLTR IFQIVRFLFP GLPEDGGFIL
DSSSSSDEGT DSLNSSTHSE TPQQGWIVSS SSLLLPVLLP RLYPPLFTLY TLEKEKEEEV
YWNCVLRLNK QPDLALLAFL GVQEKFCPVS ISVLGEIKQV LPSTKDACFA TAVETLQQIS
TAFTPSDKLQ VIQLTFEEVT QDVQALLGQD FLWCMDDLFP IFLYVVLRAR IRNLGSEVSL
IEDLTDSSLQ LGQLGFMLTT LKACYNQIQV EKTT
//
