ID A0A498N858_LABRO Unreviewed; 2511 AA.
AC A0A498N858;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=ROHU_005457 {ECO:0000313|EMBL:RXN27882.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN27882.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN27882.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN27882.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN27882.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN27882.1}.
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DR EMBL; QBIY01011940; RXN27882.1; -; Genomic_DNA.
DR STRING; 84645.A0A498N858; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RXN27882.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REPEAT 673..711
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1507..2055
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2163..2471
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2479..2511
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1467..1489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2511 AA; 284171 MW; 7E5B1F83ACFCA7AF CRC64;
MEQGLEMSAM IPALQELASA SSVEYNQAVQ KPRQILCQFI DRILTDVDVV ALELCKKTSS
EPACVMLLDF VQHIIKSSSL MFINPACLSD HFKNSENSCS DFSKWIINRL LRIAASPECE
DLHMKISSVI CSLLHLFRAK GPVLFSLFST ELICLMQDLV HINLMARQSP QWPVVVERFS
IRSGESTVYL TPTILNMPSY ASAQALLVTS LTVLTDILQG IFFPREVAII WDSTCLIMSN
GSPRLKAASM VLLTRIVTLG GFPEEHSQPF FSAYLHLLDS LPAFKESELS VFGKEFQKLS
QCVFQSEEGT CCRFERVHVN MLMERLEKLV VGGALQQLKV VEVKATLCEV FCFVLEFVPL
GYECAVQIRK ERVAAICKAL IKTIGTEDQQ EVDMMSKSEV WAAVHSRLDE LLTQMRDHRA
SQCVSTVQGL AVIFHLAARC SKHCLNGPKS GRGEKTSETS DAAQLIWLKP RVLAQVVESC
RTVMANTSNE EELEPLVEAA QTRAHCVFLL ALLSKSVCGD WRSSVYRWTL QSNSEAERAS
AVRGFPLLLH HLGVKSYSLI HEVLLNRLQD SSTQVKIELA GITGQLACCL SESSQLQFPQ
ETMPSHELLC AGLSISDSHP SQTASIGASI LTPFLLLLKP LEDMKVKQAF IRNIRHLFKH
VDLGNSDPDT KSLVSALVNL IEDPDQEVRI KFGQNIKNLL EFWNGNGFLK ELLVSRLKEA
YTNAKTSRNN ELKSTLILTT GEIGRAAEGN LVSFALLRLL HCLLSKSNPV SVAAYTEIQA
LATCRDLKLQ SFFNQYRNPI CQFLVESLHS RHVTALRCTP DQSSEALQEE AAHQRELALD
ILSHVAHVFD FPDLNRFLNR TLQVLLPFLA AKASPTASAL IRTIAKQLNV NRREMLINNF
KYIFSHLVCS CTKEELERAF HYLKNETEIE LGSLLRQDFQ GLHNELLLRL GEHYQQVFNG
LAILASFASS DDPYQGPREI TTPGRMADYL QPKLLGILAF FNMQLLSSSA GEKEKKKMAL
NSLMALMKLM GPKHISSVRV KMMTTLRTGL RYKDDFPELC CRTWDCFVRC LDPSYLGPLL
SHVIVALLPL ISIQPKETAV IMHYLIVENR EEVQDFLHEI YFLPDHPELK NIHKVLQDYR
KQTSKSTDMQ AALQLSMRAI QHENVDVRIH ALTSLKEMIY KNQDALLKHV LDSEMVEPVI
SQLVTVLLRG CQDVNPEARL LCGECLGELG AIDPGRLDLS PADTQGTGST FVSGIDDPNF
AYELLTELTK AFLAYADDVR AQDAAAYAMQ ELLSLFECRE GRTDSPGRRL WRRFPEQVQE
ILEPHLNTRY KSSQKVVNWS KLKKPIYLTS RGSKFSDWSA TWAGYLISKV RHELAGKVFN
CCSFIIKHDY KVTIYLLPHI LVYVLIGCTQ EEQREVNEEM MAVLKEGDPR LVRLQENASS
LSQLSTQTVF SMLDHLTQWS RHKLQSLSTN KRPGKHAREQ PQALATGPES SEYQSVVAFL
NSIPQDVLAK ASFRSRAYTR AVMHFESFIR EKKQNIQDHL SFLQTMYAAM HEPDGVRGVN
ALRKEEPSLR EQILEHESIG LLRESTACYD RAIQLEPDQI AHYHGVMNSM LGLGQLSTVI
TQVNGVLASR PRWKSDLNAY RVEAAWKLSK WDLVEDYLAS DCKSSTWGVR LGQMLLAAKK
QDSEAFYEKL KIARKEQVVP LSAASFECGT YQRGYEYIVR LHMLCEVEHA FTELQKESTE
AGGSKKPEPK LNWDAHLLMT QNSFRAKEPI LALRRALLGL SKGSSCEEQV GECWLQSARV
ARRAGHHQTA FNALLNAENS HLSELFIEKA KWLWSKGDVH QALIILQKGV QQCFPDDQPL
TDPKRIQIKG NAMLLVGRYM EETANFESNA IMKTYKDVTH LLPEWEDGNF YLAKYYDKVM
PMVTDNKLER QGNLIRYIVT YFGKALQFGN QYIYQAMPRM LTLWLDFGAK VYEFEKAGRS
DRAQMRAELS KINSVISEHT SNLLPYQFLT AFSQLISRIC HSNNEVFAVL MEIVAKVFLA
YPQQAMWMMT AVSKSSYPTR MNRCKEILKK AVSLNESFGK FIGDANRLTD KLVELGNKPV
DGNSSTLSMS IHFKMLKKLV EEPTFSQILI PLQSVLIPTL PSTGGANPKH DAFPGHWVYL
AGFDDTVEIL ASLQKPKKIS LKGSDGKFYT MMCKPKDDLR KDCRLMEFNC LINKSLRKDA
ESRRRDLHIR TYAVIPLNEE CGIIEWVNNT AGLRHILTKL YKEKGIYVSG TELRKLILPK
TASFQEKLKL HKDVLCARHP PVFHEWFLRT FPDPTSWYNS RSAYCRSTAV MSMVGYILGL
GDRHGENILF DSLTGECVHV DFNCLFNKGE TFDVPEVVPF RLTQNMVHAM GPMGTEGLFR
QACEVTLRLM RDQREPLMSV LKTFLHDPLV EWSKPVKGSS KTQVNESGEI LNEKAKTHVL
DIDQRLQGVI KNRNKVMGLP LSIEGHVHYL IQEATDDNLL CLMYLGWGPY L
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