ID A0A498NE42_LABRO Unreviewed; 365 AA.
AC A0A498NE42;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 9.
DE RecName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000256|ARBA:ARBA00012491};
DE EC=2.7.7.43 {ECO:0000256|ARBA:ARBA00012491};
GN ORFNames=ROHU_019338 {ECO:0000313|EMBL:RXN28395.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN28395.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN28395.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN28395.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN28395.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate +
CC diphosphate; Xref=Rhea:RHEA:11344, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:37563, ChEBI:CHEBI:60073, ChEBI:CHEBI:68671; EC=2.7.7.43;
CC Evidence={ECO:0000256|ARBA:ARBA00001862};
CC -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
CC {ECO:0000256|ARBA:ARBA00005141}.
CC -!- SIMILARITY: Belongs to the CMP-NeuNAc synthase family.
CC {ECO:0000256|ARBA:ARBA00010726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN28395.1}.
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DR EMBL; QBIY01011869; RXN28395.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NE42; -.
DR STRING; 84645.A0A498NE42; -.
DR UniPathway; UPA00628; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006054; P:N-acetylneuraminate metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:RXN28395.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transferase {ECO:0000313|EMBL:RXN28395.1}.
SQ SEQUENCE 365 AA; 41508 MW; 4A038633D219A79D CRC64;
MAPSRKKRKR ALVCENEVVH EDCSDTKRRK VNLDDSRHIA ALILARGGSK RIPLKNIKML
AGVPLIGWVI RAALDSGVFD SVWVSTDHDE IARVAKACGA EVHRRSPEVS KDTTSSLETI
QEFSRKHPDV GVICNIQATS PCLHPHHLKE ALEYITKGGC DSVFSVVRRH RFRWQEVKEG
DSQCTTPLNL DPAHRLRRQD WSGELCENGS FYFATKELIE NGLLQGGKMK YFEMKPKYSV
DIGDDIDWFR AEQKVLCYGY FGEDKPEVVK LLLRNVSGCL TDGQIYMSAN GEEMVSINTR
DQAGINMLKK KNVKAILIEK YPITKALQKK KLPKRMRCLL VDVNEKLKKV QKLMEKEGLE
WKEVA
//
