ID A0A498NHR6_LABRO Unreviewed; 2133 AA.
AC A0A498NHR6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Signal transducer and activator of transcription 4-like protein {ECO:0000313|EMBL:RXN31402.1};
GN ORFNames=ROHU_017066 {ECO:0000313|EMBL:RXN31402.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN31402.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN31402.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN31402.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN31402.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN31402.1}.
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DR EMBL; QBIY01011468; RXN31402.1; -; Genomic_DNA.
DR STRING; 84645.A0A498NHR6; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060429; P:epithelium development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16851; STAT1_CCD; 1.
DR CDD; cd16845; STAT1_DBD; 1.
DR CDD; cd16854; STAT4_CCD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 3.30.505.10; SH2 domain; 4.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 4.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 4.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 2.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046991; STAT4_CCD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF18; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA_BETA; 1.
DR Pfam; PF00017; SH2; 4.
DR Pfam; PF01017; STAT_alpha; 4.
DR Pfam; PF02864; STAT_bind; 3.
DR Pfam; PF02865; STAT_int; 2.
DR Pfam; PF21354; STAT_linker; 2.
DR SMART; SM00964; STAT_int; 2.
DR SUPFAM; SSF49417; p53-like transcription factors; 3.
DR SUPFAM; SSF55550; SH2 domain; 4.
DR SUPFAM; SSF47655; STAT; 4.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 2.
DR PROSITE; PS50001; SH2; 4.
PE 1: Evidence at protein level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NHR6};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 547..642
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 1282..1378
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 1525..1631
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 2015..2107
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 2133 AA; 245021 MW; 5E991D55DEBB9882 CRC64;
MSQWKQIQQL DIKFLEQVDY FYDDNFPMEL RQVLANWIES QDWETASNHE SMATVLFNNF
LIQLERQCSQ EQNFLHRHNL KRIFHQIQVK YKANPLHMAA VICNCLREER RILSTASMQE
QGPLEKSMQN SAALEKQKVL DNKVAVIRSS VQMLDQGVKY LEDMQDDFDF RYKTLQLRDP
VERNSLTMKQ EVTTLQEILN RLDFKRKEIL SKIADVIKEI DALISSQLNP ELKEWKRRQQ
IACIGGPVLI GLDQLQNWFT LTAQSLFQIK RQLDKLGELI LKVTYESDPI PLQRPQMEEQ
VKYLIYHLIK SSFVVEKQPC MPTHPQKPLI IKTQVQFTTK VRDLPPGKVN RQFFILTNNT
KVMDVEESTG CLSVEFRHLQ LKERKCPTGG KGNEGPLSVT EELHSLNFEA MLMLQGLDID
LETCSLPLVV ISNVSQLPGG WASVMWYNLL TDDPKNLGFF SNPLRASWSQ LSEVLSWQFS
SFAGRGLNKE QLNMLGDKLL GQHASYNDCQ VTWSKFWKEN IPGKSFSFWL WLDSILDLIK
KHLLPVWIDG YIMGFVSKEM ERALLKEKEP GTFLLRFSES HLGGITFTWV EQDENGDPKF
ISVEPYTKNR LNALPIADII RDYKVIADGV VPENPLKFLY PDIPKDEAFG KHYNSQQNKV
CPYIQTQLVP ISHRNGPVQN ACSSPEPPMS PGMFEIITQH LSPFEFESAM SLWSQLQLLD
SLYLEQVDQL YDEAFPMEIR QYLSQWIESH DWESVASNVS LATLRFHELL NQLDEHYSRL
GLGNNFLLQH NIRKIKRNLQ EHFQEDPVHM AMIIASTLNE ERKILQAALS SQATGGSSTG
SITMEQQNVL GNKVNNLKTT VQEIEQNIQV LEDVQDEYDF KRNTLQSRVE HEMNGQITKE
IQQEEMAIKQ MFVGLSMKRQ LVIKDIANAL TLAEQIQLTL ISDELPEWKK RQQMACIGGP
PNACLDQLQS WFTVVAECLQ QIRQQLKKVQ ELVQKFTYNN DPLTLGKSQL DEQALSLFRN
IILNSLVVER QPCMPTHPQR PLVIKTGVQF TVKIRSLVKL PELNCQLKIK VSIDKDLTEK
DTVKGCRKFN ILGTFSKIMN LEESSGCLAA EFRHLQLKEM KCNNRTNEAP LIISEELHIL
NFETELIQPE LCVDLSITSL PIVVISHVNQ LPSAWGSILW YNMCCSEPHN LTFFLNPPPV
KWGQFSKILS WQFSSVTKRA LNSEQLTTLA DKLLGPEAQG DHEGLINWNT FCKMSPNERG
VPFWLWIDGI LDLIKRHLLN IWNDGYIIGF LSKEREKALL RDKLPGTFLL RFSETCRDGG
ITITWVECSQ DGEPKTHSVK PYTKSDLASI SLPNVIRDYT LTAAEKIPVN PLIYLFPDIP
KEEAFGRYYT SSSDVEAETT GQTTKESQQE EMATEQMFTD LNIKREVVMK EIANVLTVAE
QIQITVISEE LEEETADVLY WKSPQHLSAA AAKLFSCGGE IALYAYTTQE TLGDKNRNSN
HSQDKVMKPK VTLKDSSSGI HFIKYIIGFL SKEREKALLR DKLPGTFLLR FNENSRCGGI
IITWVERSQD EPYTTMDLNR MSLPNIIRDY TITDGEKDPV NPLIYLYPDI PRDVAFGRYY
TSTSDAYVSS LICFNSFLVQ QTKTKPCTDN IQGKADSSQG SRMEQEKELD HKVNILKKSV
QVIEQDIQVL EDLQHKYDLK RKSSEGQVKA ETMGHTTKES QQEEMATEQM FTDINIKREM
VKKEIGNALI LVEQIQLTLI SEELPEWKKR QQMACIGGPH NTCLEQLQSW FTVVAECLQQ
MHQQLKKVQE LVQKLTYKND PLALQLDEQA LSLYKNLISN SLVVERQPYM LWHPRRPLVL
KNIVQFTVKI RLLVKLPELN SQPKVKISID KFRNFILLGL GIKVMTLDES SGCLAAEFRH
VVIKEKRPSN RSKELSITVY EELHLISFDM QLILPELCID LSITCLPVVL INPICRLSNA
LGSILWYNMC CSEPHVLKPK VTLKHSSPGI HFIKYVIGFL SREREAALLR DKLPGTFLLR
FSENSRCGGI IITWVERSQD GEPVIHSTKP YTRTDLNRMS LPNIIRDYTI SDGEKDPVNP
LIYLYPDIPR DVAFGRYYTS ASDGEMNKDR LLV
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