ID A0A498NJX6_LABRO Unreviewed; 837 AA.
AC A0A498NJX6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 03-MAY-2023, entry version 13.
DE SubName: Full=Rho guanine nucleotide exchange factor 7-like isoform X1 {ECO:0000313|EMBL:RXN32158.1};
GN ORFNames=ROHU_016433 {ECO:0000313|EMBL:RXN32158.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN32158.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN32158.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN32158.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN32158.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN32158.1}.
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DR EMBL; QBIY01011422; RXN32158.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NJX6; -.
DR STRING; 84645.A0A498NJX6; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 2.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..110
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 162..221
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 249..416
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 431..536
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 535..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 727..826
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 538..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 95310 MW; 936B8F8F8DF872AC CRC64;
MNSAEQTITW LITLGVLESP KKTLSDPEGF LQASLRDGVV LCKLLERLRP GSVHTIYEDP
RKDECLSNIR EFVKGCGLYH IEVFEANDLL QGQNFSKVLN CLVALNKATS ESGGESNSVC
SRHSSSLRIK SFDSINCSFT HRRSSRLKYN QYRSLDMSEN SAPQVLVKAR FNFQQTNEDE
LSFNKGDIIQ VTRQEEGGWW EGSLNGKTGW FPSNYVKEIK GSDKPVSPKS GTLKSPPKGF
ETSNFCKTYY NVVVQNIVQT ETEYCKELQT LLSTYLRALQ PTDRLSVSDI SHIMGNLEEI
SSFQQTLVHS LEESVKVPES QQRIGSFFLS LIPQMRSLYV TYCSNHPSAV NVLTQHSEEL
GEFMESKGAN SPGILTLTTG LSKPFLRLEK YPTLLKEMER HMEAQCQEVR KRKELELQIL
MESIRGWEGE GIKTLGSVLY MSQVLIQNHG AEEKNERYLL LFPHVLLMLS ASPRMSGFIY
QGKLPLTGMA VNKIEDSDTT KNAFEISGNM IERIQVICNN QQDLHDWVDH LHRQTKRTST
SSLKPQNVPC HTLPSHPLTP SRHSENRGVS GSPVYHTLPH LSSLGTPHSG MMWGPLEPPK
TQKPWSLSCL RPAPPLKPSA ALCYKEDLSK SPKSMKKLLP KRKPERKPSD EEFAVRKSTV
ALEEDAQILK VIEAYCTSAK TRQTLNSRSR KESGPHMLFP EEEKIIVEET KSNGQTVIEE
RSLVDTVYAL RDEVQELKQD NKRMKRTLEE EQKARKELEK IVRKVLKSMN DPSWDETNLS
LVDTVYALRD EVQELKQDNK RMKRTLEEEQ KARKELEKIV RKVLKSMNDP SWDETNL
//
