ID A0A498NK52_LABRO Unreviewed; 670 AA.
AC A0A498NK52;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Arf-GAP with Rho-GAP ANK repeat and PH domain-containing 1-like protein {ECO:0000313|EMBL:RXN32074.1};
GN ORFNames=ROHU_016503 {ECO:0000313|EMBL:RXN32074.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN32074.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN32074.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN32074.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN32074.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN32074.1}.
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DR EMBL; QBIY01011429; RXN32074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NK52; -.
DR STRING; 84645.A0A498NK52; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 43..135
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 198..330
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 401..583
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 670 AA; 76519 MW; E9E1B1AB7C30030C CRC64;
MQKCFINLKA EEDRKETVNW REREDSIDIQ CTDFPDFSED FRQIVKAGWL EKTPPKGGKI
YQRRWVQLDS EYLRYFQSIK EVYSKRMVSL GSVDKVVSVG DLRFELRSQS RTFLFRAEST
QERNDWVCCI EKILSDRKQH LEPRNLFFRN GSVNISFEGY MEMLSPRTKV YTLISKDKLF
IFKSHEEYFQ GVGITDIDMR MANVRDGENK RSFTLTTPYR AFSSSMPEWA SINLCVLLCE
KCAGAHRSLG QNVSKVRSLK LDERVWTDDL IRVFLLLGNG KANQFWGANI PPSESLCSSA
NSEKRLEHIT AKYKDGKYRK YHILYGQQEA LNSALCSAVQ SGDLLETLSL LNCGADINCN
TGIPELPTPL SLAKRSSQTV QAELLMQNLS TESFTRVDKD VSIRSQCGYL FKTASSARPI
TDHKTKAGLM SSGIYRKSGI NSRVTKLLER FQNDARSVTM LESDYSVDDM ANTLKRFLRE
VKDGVFNGQE NSDSWLRAAG LKDRGEKVHR YQILLSNLPE VNRETLKALI HHLVCVQHLS
DENQMTIRNL GIVFGPTLFQ TDGKDVTGSQ VVEELIQNYC SIFNVSESDL QRQLNMTSEI
LNKHKSQIAA DMTVVKLVSV VLELKGIQQA NEEFWSCYEV LEKEEMEDWI GIGIPRVRGD
LAHIKNDGAT
//
