ID A0A498NMI7_LABRO Unreviewed; 185 AA.
AC A0A498NMI7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 22-FEB-2023, entry version 10.
DE RecName: Full=Transmembrane protein 208 {ECO:0000256|ARBA:ARBA00015033};
GN ORFNames=ROHU_004533 {ECO:0000313|EMBL:RXN32737.1}, ROHU_024714
GN {ECO:0000313|EMBL:RXN20853.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN32737.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN32737.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN32737.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN32737.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as a negative regulator of endoplasmic
CC reticulum-stress induced autophagy. {ECO:0000256|ARBA:ARBA00003220}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM208 family.
CC {ECO:0000256|ARBA:ARBA00009950}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN32737.1}.
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DR EMBL; QBIY01012630; RXN20853.1; -; Genomic_DNA.
DR EMBL; QBIY01011349; RXN32737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NMI7; -.
DR STRING; 84645.A0A498NMI7; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008506; SND2/TMEM208.
DR PANTHER; PTHR13505; TRANSMEMBRANE PROTEIN 208; 1.
DR PANTHER; PTHR13505:SF7; TRANSMEMBRANE PROTEIN 208; 1.
DR Pfam; PF05620; TMEM208_SND2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 160..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 185 AA; 21225 MW; BDA2D649771186EC CRC64;
MEEKDALLLI VKPKGKVGTK GKKQIHEENQ DTLKFYCRII LGANAIYAAV DLLLFYNSSS
FWTWFFLLFA VAVYIGSYRS MSAMAKPAFA EDGSLLDGGI DLNMEQGMAE HLKDVILLTA
IVQVLSTLSS YFWYFWLLAP ARALHLLWVN FLGPWFSAES QAAPEDNEKN DKKQRRQERR
QMKKF
//
