ID A0A498NMX0_LABRO Unreviewed; 1063 AA.
AC A0A498NMX0;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Vesicle-fusing ATPase {ECO:0000256|ARBA:ARBA00019912};
DE EC=3.6.4.6 {ECO:0000256|ARBA:ARBA00012674};
DE AltName: Full=N-ethylmaleimide-sensitive fusion protein {ECO:0000256|ARBA:ARBA00033363};
DE AltName: Full=Vesicular-fusion protein NSF {ECO:0000256|ARBA:ARBA00030543};
GN ORFNames=ROHU_015862 {ECO:0000313|EMBL:RXN33108.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN33108.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN33108.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN33108.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN33108.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000161};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN33108.1}.
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DR EMBL; QBIY01011302; RXN33108.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NMX0; -.
DR STRING; 84645.A0A498NMX0; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0035494; P:SNARE complex disassembly; IEA:InterPro.
DR CDD; cd19504; RecA-like_NSF-SEC18_r1-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.25.40.570; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.10.330.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR004201; Cdc48_dom2.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR003338; CDC4_N-term_subdom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR040773; Rpn6_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR039812; Vesicle-fus_ATPase.
DR PANTHER; PTHR23078:SF3; VESICLE-FUSING ATPASE; 1.
DR PANTHER; PTHR23078; VESICULAR-FUSION PROTEIN NSF; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF02933; CDC48_2; 1.
DR Pfam; PF02359; CDC48_N; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF18055; RPN6_N; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01072; CDC48_2; 1.
DR SMART; SM01073; CDC48_N; 1.
DR SMART; SM00753; PAM; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF54585; Cdc48 domain 2-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50250; PCI; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NMX0};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 200..379
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 1063 AA; 118330 MW; 6D5E41FAC93DE165 CRC64;
MKVKRDIQDN DEEAVRVKEQ SILELGGLLA KTGQAAELGG LLKYVRPFLN SISKAKAARL
VRSLLDMFLD MEAATGQEVE LCLECIEWAK SEKRTFLRQA LEARLVSLYF DTKRYQEALQ
LGSQLLQELK KMDDKALLVE LQLLESKTYH ALSNLPKARA ALTSARTTAN AIYCPPKLQA
ALDMQSGIIH AAEEKDWKTA YSYFYEAFEG YDSIDSPRAI TALKYMLLCK IMLNSPEDVQ
ALISGKLALR YAGRQTDALK CVAQASKNRS LADFEKALTE YKAELRDDPI ISTHLAKLYD
NLLEQNLIRV IEPFSRVQIE HISELIKLSK TMQAARCPTD ELSLTNCAVV SEKDLQSGQH
VTVRTTPTHK FVFTVKSHHS VLPGTIAFSL PQRKWAGLSI GQEVEVANYN FDKSKQCIGA
MTIEIDFLQK KSTDSSPYDS DKMAAEFIQH FNNQGFTVGQ QLVFSFCDKL FGLVIKDIEA
MDPSILKGEP ASGKKQKIEV GLLVGNSQVI FEKSESSSLT LVGKAKTKEA RQTIINPDWN
FEKMGIGGLD KEFSDIFRRA FASRVFPVDI VEQMGCKHVK GILLFGPPGC GKTLMARQIG
KMLNAREPKI VNGPEILNKY VGESEANIRK LFADAEEEQK RLGANSGLHI IIFDELDAIC
KQRGTGASST GVHDTVVNQL LSKIDGVEQL NNILVIGMTN RPDLIDEALM RPGRFEVKME
IGLPDEKGRL QILNIHTSKM REFNLLSGDV DVKELAAETK NYSGAELEGL VRAAQSTAMN
RHIKATSTVE VDMERAEKLQ VTRSDFMASL NNDIKPAFGT NQEDYSSYIM NGIIKWGDPV
TRVLEDGELL VQQTKNSDRT PLVSVLLEGP PHSGKTALAA KISEDSQFPF IKICSPDKMI
GHSEISKCQA IKKVFDDAYK SQLSCVVVDD IERLLDYVPI GPRFSNLVLQ ALLVLLKKTP
PHGRKLLIIG TTSRKDVLQE MEMLDAFSTT IHVQNISSGE HLVEALEMDQ AYRVSKFLSL
LKEEGATGDQ AENSVVNLCT VNFRQLSACL IYSIERISDT HYS
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