ID A0A498NPP2_LABRO Unreviewed; 1340 AA.
AC A0A498NPP2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Signal-induced proliferation-associated 1 2 isoform X1 {ECO:0000313|EMBL:RXN34012.1};
GN ORFNames=ROHU_015144 {ECO:0000313|EMBL:RXN34012.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN34012.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN34012.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN34012.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN34012.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN34012.1}.
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DR EMBL; QBIY01011215; RXN34012.1; -; Genomic_DNA.
DR STRING; 84645.A0A498NPP2; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 555..772
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 913..989
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 41..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1316..1340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 147995 MW; 79D2CEEB937712D5 CRC64;
MQTDDLFAKK LQALNGNMGP PGANTQGTPA VPKMGVRARV SDWPQKKDGH GPPPRYESLM
TTFQNGQPNQ LPEDVVKQSP GSPPNPSFLE AKYGLGELLS QSPGKVHHAL QKRSNSDVTI
SDIGAEDMDQ TAINPNTGAT LHREYGSTSS INRQGVPDEG FFGNLKVFQP ELSEQPSAPP
PHGFPEFRRY EAAISPSLQT AAQIARGDIV CIPNYSDYVD SSLFYSRERE KSFLQRQKSE
KGETSIFRRL KTMKSEQRQL SEHDDCSRHG RPLSFQRCFA HYDVQSVLFN ISEAVTNRAN
LARRKNITTG ASAASQHQIG GGLDSPDPLS ICEPPLESCE ELAQKANMDP DEGDGKSNGL
VLSCPYFRNE IGGEGERKLS ATKPNSGPHN NVGDIYTIES TLSSHCTNAG VSVLEMAREN
YASRENYAVP RDCIKRYIIE HIDMGAYYYH KFFFNKEHQN YFGVDENLGP VSVSIRREKL
EEGKEGPQYN YRVVFRTSEL TTLRGSILED AVPSTAKHGT SRGLPLKEVL EYVVPEVNIQ
CLRLATTSPK VPEQLLKLDQ QGLSYQHKVG ILYCQAGQST EEEMYNNESG SPALEEFLDL
LGQKVRLKGF NKYRAQLDNK TDSTGTHSLY TTYKDFELMF HVSTMLPYTP NNRQQLLRKR
HIGNDIVTII FQEPGAFPFT PQNIRSHFQH VFIIVKVHNP CTEHVCYSVA VARSKDVPVF
GPPIPKGVMF PKSAVFRDFL LAKVINGENA AHKSEKFRAM ATRTRQEYLK ELVENFTGAT
PVDASGAKFS FITLGAKRKE RSRPRNNAHL YSTGAITWSV VARDSCQSTD IGCLLAISRD
FVALIEEASR EVVFNCYCKD VIGWSSSSMV GRVKLFYERG DCVVFSVQDG CPEEVREVVQ
RLEMITRGCE ALEMTLRRNA LGQLGFHVNF EGVVADVEPF GFAWQAGLRP GCRLLEICKV
AVGTLTHEQM IDYLRTSTPV TVVVIQPHED GTPRSADAAS VTSSVSEQEF LLAYLGASEL
YRVPVVEYKT LGTGPGWHRM THVPQALPLS RVSPTQGPDR PSPSQQMFQY AQAAISRSTS
FDKKYQDGSR VLQDFEMVQS PSGNPGQHYC SSPSNQSTSS DPGPCGTWAQ KASYDGSQSP
ALHDQPEEKE GDRDHKLERT RSAGSPCVPE AKWHIPSTKI LNRGLQRQGA KESPGKFPRT
REKSCHSHCS SHSSNNTLSS NASSGSDEKH FGSGDPMDPE SLGLTYIKGA STDSGIDTAP
CMPPPPPALP LTAVGPSRMV TRDGRVETGL PWPLEYHEDG ETDEGRAKMF ISQGYVPATP
TGHTTDGSTG DLSEISSLSR
//
