ID A0A498NPP4_LABRO Unreviewed; 585 AA.
AC A0A498NPP4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=THO complex subunit 6-like protein {ECO:0000313|EMBL:RXN33669.1};
GN ORFNames=ROHU_015422 {ECO:0000313|EMBL:RXN33669.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN33669.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN33669.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN33669.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN33669.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat THOC6 family.
CC {ECO:0000256|ARBA:ARBA00009728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN33669.1}.
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DR EMBL; QBIY01011254; RXN33669.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NPP4; -.
DR STRING; 84645.A0A498NPP4; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16470; RING-H2_RNF25; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR042626; THOC6.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR44411; THO COMPLEX SUBUNIT 6 HOMOLOG; 1.
DR PANTHER; PTHR44411:SF1; THO COMPLEX SUBUNIT 6 HOMOLOG; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00400; WD40; 1.
DR Pfam; PF17123; zf-RING_11; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NPP4};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 87..128
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 372..439
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 585 AA; 65781 MW; 0C069304C765F3E2 CRC64;
MSVFSQSFSP CGRFLAAGNN YGEIAVFSLS AALSPDASEG SQKPILNFTA HDGPVFSLLS
TDTHLLSAGN GEISAWSWAE LIKKSVLKGH TDYIHCLCFK EREDEILSGG EDGAVRIWDS
RTNRPVHCIE VFKYELCGGG PSLSLWHLRS MSPTSVFPLP GCQREAVFYQ DLIMSVGEGP
FVSHCLHGGT VKAQIPCTQS SLNTLALNLK NTEHRMWEKV VCSYDSQTTH SLVSLLDPKG
SYITTIGVDF KIRTVEIDGE RVKLQIWDTA GQERFRTITS TYYRNTHGVI IVYDVTNIES
FGNVKRWLNE IAQNFGNKND DPSKKQVDTQ EAQRFGELYG VRLFETSAKE NINVEERAKE
ILTESNIPHG NCVICLYGFK EGEVFTKTSC YHYFHSHCLG RYITHSEIEL KDRERELEED
KTRDRTEEEE LAVVCPVCRE PLTYDLDALL SSPAPVFTQQ EDAVIGGEFK KKWAALQKVL
ERQKEKGGVI DPEAESNRFL IHINELMFLT LLERMPLVPN LVSHSLPHPK IPLMQPKPLK
VTTPRANRSA LALMREGSKV ISREVVEEEE AGEVDQHVTR CLHLG
//
