ID A0A498NQB9_LABRO Unreviewed; 1411 AA.
AC A0A498NQB9;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=ROHU_015163 {ECO:0000313|EMBL:RXN34031.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN34031.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN34031.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN34031.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN34031.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|RuleBase:RU004273};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|ARBA:ARBA00008294, ECO:0000256|RuleBase:RU004273}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN34031.1}.
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DR EMBL; QBIY01011215; RXN34031.1; -; Genomic_DNA.
DR STRING; 84645.A0A498NQB9; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 3.60.21.10; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF00084; Sushi; 3.
DR Pfam; PF00201; UDPGT; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00032; CCP; 3.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 2.
DR PROSITE; PS50923; SUSHI; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004273};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RXN34031.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 436..471
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 476..511
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 523..577
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 578..632
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 972..1036
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 872..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1411 AA; 159046 MW; 16EEA0EC43BB7C9E CRC64;
MKDGQRKAIK AAILIQRWYR RYVARLEMRR RYTWNIFQSI EYAGEQDQLQ LSSFFSFMLD
NFTQMNGNGP DLISHLLDSV VDPLTEEVRQ LKYEQIVVPE SYSGPRLSFP LSVTDTNALL
SAFKEEQNGL PSAENPYIFN GDFVDRGKKS TEIIIILFAF LLLYPDHMHL NRGNHEDHIM
NLRYGFTKEV MQKYKTHGRE ILQLLQDVFS LLPLATVIDN KVLIVHGGIS DKTDLDFLST
VERHKNGLPS AENPYIFNGD FVDRGKKSTE IIIILFAFLL LYPDHMHLNR GNHEDHIMNL
RYGFTKEVMQ KYKTHGREIL QLLQDVFSLL PLATVIDNKV LIVHGGISDK TDLDFLSTVE
RHKVVDILWS DPKNQNGCSP NSFRGGGCYF GPDVTQTLLQ KHGLCLLIRS HECKQEGYEL
CHSGQVTPNL AETLYRYRTD LEIIFNIIDK DHSGQISIEE FRQTWKLFSS HLGVAVNDQT
IDDMARSIDF NKDGSIDFNE FLEAFRVVHK LDVKEQQQGI ADKGCSGFGN LENGRMFFRY
GGLYVTFTCN PGFRIHGYRT SSCVSGQWAR DPPLCVASGC PSPGDLLHGN TVVSKDRSLA
FFSCDTGFSL FGSALLFCKG KSWNGTKPVC KVADIMSVLH LKQEPLHSHD VPSLKVHLHS
HLNTLAITAP KDAFLKTALL GAPHIKLDFT DLKQKNIEKP VEKKPSKILL FDKTQHSGRP
EPISNFENFK DPIRNADLQK SMPVTSANVN TISLATSFQK SSFLSTTPTS FVIPAMNAQQ
VTDQTFTEAP YRRNKTGYQS TIDQSVILAA KTLPEYIKNN SYWISTTSAP NIITLGTDVH
LQSETFIRDP HKVTTESFAL VSKHESVSFA PIMGSTAPST SGELYEQKPD VQETSPPPDT
TGYTSSTMEV LTTTTQLVSD LHLATPTDVH HFTNVTDDHQ INGKSNQSDS KQAFDTSAWK
DLPRFPTRMR RPVCPYPPFP SHGTFYFRSI KNPSPHQYKH YIQYACYPGY TLTNGDVYSY
CQHNGQWSGQ TPLCLELTPC SLNNGGCSQI CHVNEQNRAQ CLCKPGFLLL EDQRTCRAVG
ATIQPRKPVW TGSLLVVPMD GSHWTGVKAV AEEMGRRGHK VTVVIPEVSV LLGPGKHYTT
RTFPVPYGKQ QLDELQARNA EVMESKQLPL LEKISTRISN MRKFVDLQRA TAESLLFNQE
LVEFLRKQNF DAVLTSPAVP TGAILAYNLS LPAVYMLRGL PCGLDSTATA CPNPPSYIPR
FFTNNSDRMS FRQRVLNVLV SIVEPLLCRL IYWSTEDVAS RFLQRDVRVA EILRSGAIWL
LRYDFSLEFP KPLMPNMVLI GGINCALKNP LTKRDVSLTE ILSTGAIWLM RYDFSLEFPK
PLMPNIQLIG GINCEIRNPL TKVSSSFVLI T
//
