ID A0A498NRT2_LABRO Unreviewed; 680 AA.
AC A0A498NRT2;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=ROHU_015097 {ECO:0000313|EMBL:RXN34257.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN34257.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN34257.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN34257.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN34257.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN34257.1}.
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DR EMBL; QBIY01011202; RXN34257.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NRT2; -.
DR STRING; 84645.A0A498NRT2; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17978; DEXHc_DHX33; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RXN34257.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RXN34257.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 57..225
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 250..423
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 680 AA; 76346 MW; 8CC6E134D9CC70C7 CRC64;
MPHDPDPPPA KRFKPGSPFF RLDKKPDMLL PRAGHAIVSV DAQRKQLPIY QSRTQVINQL
RQLHNAVFIG ETGSGKTTQI PQYLYEAGIG RQGIIAITQP RRVAAISLAG RVAEEKKVQL
GKLVGYTVRF EDVTSSETKL KFMTDGMLLR EAIGDPLLLR YTVVILDEAH ERTVHTDVLF
GVVKAAQRKR TEQNKIPLKV VVMSATMDVD LFSQYFNKSP VLYLEGRQHP IQIYYTKQTQ
TDYLQAALVS IFQIHQEAPP SHDILVFMTG QEEIEALART CRDISKHLPE TSGPMTVIPL
YASLPPVQQL RVFQPAPKGS RKVVISTNIA ETSITISGIK YVIDTGMVKA KRYNPDSGLE
VLAVQRVSKA QAWQRAGRAG REAAGSCYRL YTEEEFDNFA NMTVPEIQRC NLASVILQLL
ALGVPDVLNF DFMSKPSPES LRTAVEQLCI LGAVDRKDDQ VSLTPLGKKM ACFPLEPRFS
KTLLISPDFS CTEEVLTIIS LLSVDSVLYN PPARRDDVLA VRKKFISSEG DHMTLLNIYR
AFKKVSGNKE WCRENFVNSR NMGLVLEVRA QLRDICIKMN MKLESSLSDL VNVRRCLAHG
LFMNAAELQP DGSYVALDTH QPVAIHPSSV LFQAKPACVV FNELLHTSRC YMRDLCLVDA
DWLQEAAPEY FRRKLRAMKS
//
