ID A0A498NS93_LABRO Unreviewed; 951 AA.
AC A0A498NS93;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Rho GTPase-activating 39 {ECO:0000313|EMBL:RXN34972.1};
GN ORFNames=ROHU_035961 {ECO:0000313|EMBL:RXN34972.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN34972.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN34972.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN34972.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN34972.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN34972.1}.
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DR EMBL; QBIY01011161; RXN34972.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NS93; -.
DR STRING; 84645.A0A498NS93; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF1; RHO GTPASE-ACTIVATING PROTEIN 39; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NS93};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 29..56
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 580..737
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 748..946
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 70..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 106555 MW; B61768E58A6BACEF CRC64;
MYANLLTGEC VWDAPAGVRI KRSGQDQWWE LFDSKTSRFY YYNASTQRTV WHRPHSCDII
PLAKLQTLKQ NTNTAPPTAT TTSASADSSP ARSAVSTTSS QEQEEKTSTA EEGERFRWGT
GTRERMLIKV SDREPSFLTQ GNGYSSSSPR SRRSSSNAPS DPEATPLSLP DRPTTQSPFL
KRAELGGTQR RCSGDSQPSS PRYAYEPPLY EEPPSEYQSP PIYEEPPTDM HCDQAFFGTD
RSPARKPGLF HSPKQSPSPY GQLVLTRQRS STPEKTPNQG DRDYSSSGRD YSSAGRDYSS
SGRDYSSGMR DYSSGGRDYN SSGREYSAAG REYVKQLVYV EQSGSSPRFR TTERLLSYGT
TSSNSLSAGF SYGGSFTLQH SHDLNGGNRK RKNRKPSLPG GEGDGMGSGL GAMITQARLA
WEAQQMLHQR GGVSSDQGSK DGYESDGATP LPLPGPVVRA FSEDEALAQQ ESHWKRATLD
RLAFPQTLLE KSLSVQTNLA SPEPYLHPSQ SEDLGACSQF EASRNARNMM PSASCGVFPE
FTLRKPSSET DIENWASKHF NKHTQGLFRR KVSIANMLAW SSEPIKKPMI MTTDRTVKRE
AVELFKLIQT YMGDRRGKVE PLAVALEVAV RGWSCQGLRD ELYIQLCRQT TENFRYDSLQ
RGWELMAICL AFFPPTPRFH NYLEGYIYRH MDPLNDTKGV AISSYAKYCY RKLQKAALTG
AKKGLNKPSI EEIAHARNAI FRPSMFGSSL EEVMAMQKDR YPDRQLPWVQ TRLSEEVLSL
NGDQTEGIFR VPGDIDEVNA LKLQVDQWKV PTGLEDPHIP AICLCLSVCL ASLLKLWYRE
LEEPVIPHEF YEQCIMNYDS PAAAVNVVLN LPHINKLVLC YLIRFLQVFA QASSVSMTKM
DVSNLAMVMA PNCLRCQSDD PRVIFENTRK EMSFIRVLIQ HLDTSFMDGV L
//
