ID A0A498NSM6_LABRO Unreviewed; 967 AA.
AC A0A498NSM6;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Receptor-type tyrosine-phosphatase N2-like isoform X3 {ECO:0000313|EMBL:RXN34778.1};
GN ORFNames=ROHU_014699 {ECO:0000313|EMBL:RXN34778.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN34778.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN34778.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN34778.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN34778.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 8 subfamily. {ECO:0000256|ARBA:ARBA00025723}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN34778.1}.
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DR EMBL; QBIY01011165; RXN34778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NSM6; -.
DR STRING; 84645.A0A498NSM6; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NSM6};
KW Receptor {ECO:0000313|EMBL:RXN34778.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..967
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019820175"
FT TRANSMEM 584..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 715..957
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 898..948
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 159..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 967 AA; 108607 MW; C00B1AD9719A8D72 CRC64;
MESFHLFLTI LAFRASLASA ADRKFGCLFE EGLCLNYEVC LNDGMLGRCE AAPLTGVYTY
DVTPATVQRF RTLLQRLAHR GLSWEDDITQ QVLSNEFSKL RKVSLPLPEP RPQGYGTAVG
DRRMKSSEAE VRKTLKYLQH LGLLPKTSHK MAELQYYRSG EPRPETDSSP PEFIPEVPYK
SKSYPDLSRY QSDAAQAPQQ EEGPDLLAAA LQKYLSKNKP LQPGLGDRSR TDRFYSKDGS
TKSSTSDSLS PVDESFIWKV LRNVGRHSVD VKSLKAADLD KLAVLIADAL QVVEQQAGQG
ETPRDLETQQ SPEDETEDMQ YEDQRPESYA VDQTPEDRAQ NQREEDEESS SVTQKTVQTN
PPVTEGQTVV EEKRTMDNKQ DVGFLGKLLE YLDKTSSSEP EAVDKGRGVS VETVRSRTTH
REVGMQKKAI ERVEEVEGWV QAAAIAPSSG LKENPAPHRK NMKVQDLQLD VQSNAKSDIY
GYIITDTENL PTDKGLYLME LVARKAKIQM TDFSELSVVS PAVTFQVRPN AQNATTEDVA
NVAVHRKDEL EKEAKVKIVE AGVTDRSKLN QIPTKYSRSE SLKFLILTVI SIICITGVLL
ASSVVYCLRH RSHHKLKEKL TNLGSDPTTD ATATYQELCR QRMAVKPPVE KSDPIHSSRI
NSVSSQLSDG PMPSPSARTS TSSWSEEPAH SNMDISTGHM ILAYMEDHLK NKNRLESEWE
ALCAYQAEPN ATTIGQRDGN VKKNRTSTVI AYDHCRITLK MENNQGNSDY INASPIMDHD
PRNPAYIATQ GPLPSTVADF WQMVWESGCV VIVMLTPLTE NGVKQCYHYW PDEGSNLYHI
YEVNLVSEHV WCEDFLVRSF YLKNMQTNET RTVTQFHYHT WLNDQTPETS QTLLDFRSDG
AGRTGTYILI DMVLNKMAKG AKEIDIAATL EHLRDQRPGM VQTKDQFEFA LTTVAEEVNA
ILKVLPQ
//
