ID A0A498NT12_LABRO Unreviewed; 886 AA.
AC A0A498NT12;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Complement C3-like protein {ECO:0000313|EMBL:RXN35011.1};
GN ORFNames=ROHU_003908 {ECO:0000313|EMBL:RXN35011.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN35011.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN35011.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN35011.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN35011.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN35011.1}.
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DR EMBL; QBIY01011153; RXN35011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NT12; -.
DR STRING; 84645.A0A498NT12; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR Gene3D; 1.20.50.70; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR040839; MG4.
DR PANTHER; PTHR11412:SF167; COMPLEMENT COMPONENT C3B, TANDEM DUPLICATE 1 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF17789; MG4; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00104; ANATO; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NT12};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..886
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019788596"
FT DOMAIN 576..611
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT REGION 533..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 98641 MW; BAAFF5C17D14DADB CRC64;
MLFPLLLWTA LLCHISDGSD LVIDQSPTFS VLAPAKIRPG TKQNILLEGH KLSQALTVSI
RVYDYPTSQT VLMTGSVTLN SDNNYSALTA IEIDPIVLQP DEKKKYVKLV AQFGTYHNAE
RILPVSFRSG YIFIQTDKPV YNPGDTVRYR AFVSDTEFHA AERTISLEIQ VNVTGNDVDV
ITLNGGIVSL TMEEIKKAYP DTNSLLGSSV YVKASVMTSS GSDLVEAEKS GIKIVMSPYV
LSIKDTPKYF KPGLPLGMMV TVSDHNRSPA QNIPVKISFL EKPVTEHGGT IKVYIDMPEI
YSSQTLKVET ADPLLKPEQQ AIQEMHVEPY AAFNDYRNYL HISMDSSRVV VGDTVNFNAH
IKCNPPERKQ LVEQMTYAVL SKGNIIHVVR KNVKDLDVIN LPLVVTTEML PAFRFVAYYT
LPWQPKAEVV ADSLFVDVED RCVGSLSVGS VEGEELTSYS PGSNITFEVK GDLGAKVSLV
AVDNAIFLLS KSRLTQKKVW EVVGQGDMGC TAGGGRDNMG VFSDAGLMFY SSTGGSTDDR
KDSSSMSRRR RSAAKLQLKE QLEKEYFREG EFLQRCCMDG MREIPMPHSC YRRSRYITED
QSCVSAFLRC CAKYRGEELG VVTRPPTTTP PPIIVPPSRD DNSLRPGRGG GDFALSVELA
QAGRYNDVEE EEEEEEEEFD EDDLADLKDN YVRSKFFESW LWTDIRLPSV PKSDGLAVFP
VNAVLPDSIT QWGFLAVSAS PQTGFCVAEP YKVRTWKPFF VDLRLPHSVS RNEHVEIKAV
LHNYSNLKLQ VFLILEKTED MCSVAFTKRN RQQVSVEASS SKVISYTIIP LKTGELPLQV
TAIVPSLMAQ DAVRKNLHVV VEGIQTIKVK SFVLNPAEGR VPNRNF
//
