ID A0A498NUD1_LABRO Unreviewed; 830 AA.
AC A0A498NUD1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Unconventional myosin-VIIa {ECO:0000313|EMBL:RXN35286.1};
GN ORFNames=ROHU_014286 {ECO:0000313|EMBL:RXN35286.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN35286.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN35286.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN35286.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN35286.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN35286.1}.
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DR EMBL; QBIY01011128; RXN35286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NUD1; -.
DR STRING; 84645.A0A498NUD1; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd04046; C2_Calpain; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR033884; C2_Calpain.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NUD1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572}.
FT DOMAIN 127..251
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 447..830
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT BINDING 540..547
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 830 AA; 95277 MW; 85B3EF0FFBFADE0F CRC64;
MDFENFCKYF TDLILCRLIN TSYLSIHKTW EEEVMRGSWS RHDDPLKNRS GGCINHKATF
LQNPQVELNR TYRMHAIQKT VGSSIYINSR SVFLRKDLKE GRYVIIPTTF DPSLQGDFLL
RIFTDVPAAF KELTLDEPIH TCWTGCCGYP KLVTQVHVHR ADGLKAQDSD GSSDPYVIIS
CEGEKVRSAV HKNTQSPDFD VKAVFYRKKP KEPIRIQIYN HNLLKDSFMG QAVLNGDLSD
LQQLHTVHLR DKGNRQNSDL SGLVSGLVWR RLMSRRKHKQ HSHGHSTAGP HFQERDVVIH
GFIDSQRYED PSCFCLSQRN ERWCDFCPVK ERRLKRETLE FCALRGLGFD LVRMYKRRDY
VELYEKDQAK WALLRNVNTV VKHTTLLPGD YVWLDLKTGR EFEVPVGAVV KLCDSGQIQV
LDDEGNEHWI SPQNATNIKP MHPTSIHGVE DMIRLGDLNE AGILRNLLIR YREHLIYTYT
GSILVAVNPY QLLPIYTADQ IRLYTNKKIG EMPPHIFAIA DNCYFNMQRN NKDQCCIISG
ESGAGKTEST KLILQFLAAI SGQHSWIEQQ VLEANPILEA FGNAKTIRND NSSRFGKYID
IHFNKRGAIE GAKIEQYLLE KSRVCRQARD ERNYHIFYCM LKGMTPDQKK KLGLGKATDY
TYLTIGDCTV CDGRDDQKEY SNIRSAMKVL MFTDKENWEI SKLLAAILHM GNLNYEARTY
DNLDACEVVR CSDLTTAAVL LEVDLKDLMN CLTSRTIITR GETVSTPLSI EQALDVRDAF
VKGIYGRLFV WIVEKINAAI YKPPSMELKA VRRSIGLLDI FGFENFTVNR
//
