ID A0A498NW29_LABRO Unreviewed; 691 AA.
AC A0A498NW29;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Integrin alpha-M-like protein {ECO:0000313|EMBL:RXN35714.1};
GN ORFNames=ROHU_003603 {ECO:0000313|EMBL:RXN35714.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN35714.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN35714.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN35714.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN35714.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN35714.1}.
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DR EMBL; QBIY01011078; RXN35714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NW29; -.
DR STRING; 84645.A0A498NW29; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|RuleBase:RU003762, ECO:0000313|EMBL:RXN35714.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A498NW29};
KW Receptor {ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 135..313
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 361..421
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 423..481
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 691 AA; 76805 MW; B6BA7D1B4F72B684 CRC64;
MASVTDSQHQ CGEIFSFTHD TEETSFIKEN TEKIFSFTHN AEQTGKLVLS RKHLKEIFFH
SGDDVLEEYE VTITLSGMRR ALLGHIPETR VCGPTIPKNC DVTTYNGMCF KISSDNVVSK
SVPKTLRECP TSQIDIAFLM DGSGSVNDVD FNKMKNFVVE MIKSFIDHDT QFAIAQFSTY
CTVHYKFQQV KNAKAWEDAV TKIGQIKGWT NTAKAIKQLV RELFVSERGA RPSASKILVV
ITDGESTDKD DSLTEAVQQA QAKKITRYAI GVGNAFSVDK AIKELATIAS LPTNKHVFKV
TDFDALASIS EQLKENIIAI EGYSLAIATM SRTKYAIMGA PRHKHKGQVT VSRIDGISSK
LQELDPPKPQ IGSYFGAELC VVDLNSDSRT DLLLVSAPTY IEPDQEGKVF VYTFDRRSYF
VFSGTVLVGM AGQRGRFGSS LASPADLNGD GYMDVLIGAP LEEDGQGSIY IFNGEAYKIN
PTYSQRIAGL SVQPGLRFFG ISLSQSSPDQ SADNLPDIAV GSMEAVLLLR SRPIMYLETN
VTYNPSKIPT SGTDQSLKNT MTVCFTMRPY NHNIRDLTAN INYTITLDAK RQKYRAYFTP
KNRFNNFMMN MNMKETCNSH PFFIDGFSED ALNPLSNQLT FTFEGLPSAT FPRPILLPGT
KNTDHNLDFE INCGRDAICV DDLRMDFNFS G
//
