ID A0A498NXB4_LABRO Unreviewed; 768 AA.
AC A0A498NXB4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Endothelial lipase-like protein {ECO:0000313|EMBL:RXN36850.1};
GN ORFNames=ROHU_014047 {ECO:0000313|EMBL:RXN36850.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN36850.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN36850.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN36850.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN36850.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN36850.1}.
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DR EMBL; QBIY01006896; RXN36850.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NXB4; -.
DR STRING; 84645.A0A498NXB4; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0004465; F:lipoprotein lipase activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR002330; Lipo_Lipase.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR000734; TAG_lipase.
DR InterPro; IPR038717; Tc1-like_DDE_dom.
DR PANTHER; PTHR11610:SF13; ENDOTHELIAL LIPASE; 1.
DR PANTHER; PTHR11610; LIPASE; 1.
DR Pfam; PF13358; DDE_3; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF00151; Lipase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00822; LIPOLIPASE.
DR PRINTS; PR00821; TAGLIPASE.
DR SMART; SM00913; IBN_N; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 309..445
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 601..673
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 768 AA; 86895 MW; BC8DDF5495F1DFC1 CRC64;
MDPEVLHDRI KYNMRKSFDL DEDGCYLQPG KRESIEECGF NPSVKTILII HGWTMSGMFE
SWMHKLVAAV QRRESEANVV VVDWLGLAHQ LYPDAVNHTR RVGQSIATVL DWLQDEVQLQ
LQDVHMIGYS LGAHVAGYAG TFVKGNIGRI TGLDPAGPMF EGAASHKRLS PDDADFVDVL
HTYTRGALGV SIGIQEPIGD IDIYPNGGDV QPGCSLGDVL STAAAGNFVE VMKCEHERAV
HLFVDSLMNK DHVSYAFQCT DPDRFKKGIC LSCRKNRCNS IGYNAKKMRK RRNSKMYLKT
RADTPFGGYH YQMKMHVFDR KNADDADPTF YVTLHGQHND TVNLNVDIAD GVGLNLTNTF
LVFTEEDIGE LLKISLRWEG PSDSWSSVLK HLRSSFWSWS SSQDKVLEVR RIRVKAGETQ
KKFTFCAEKT ELSPGQEITF TKCRDGWEVK PRKRIQRLPP LGGRGKLLNE EQELAIVNMR
VMELEANQVP HEIIYVDESG FNLAKRRRRG RNIIGQRATV TVPGQRGANI TMCTAISNNG
ALLHKCQIGP YNTDRLLLFL EDLHERLVPE LYLMDIQSAS SVVLQALTQA TSQDTAVLKP
AEEQLRQWET QPGFYSVLLS IFNNHLLDVN VRWLAVLYFK NGIDRYWRRV APHALSEEEK
SSLRAGLITN FNEPINQIAT QIAVLIAKVA RLDCPRQWPE LIPILLESVK VQDSLQQHRA
LLTFYHVTKT LASKRLATDR RLFQDSFLPS HSTGSQPEND FMFSLLNL
//
