ID A0A498NZ17_LABRO Unreviewed; 798 AA.
AC A0A498NZ17;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Alpha-2-macroglobulin-like protein {ECO:0000313|EMBL:RXN37141.1};
GN ORFNames=ROHU_002311 {ECO:0000313|EMBL:RXN37141.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN37141.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN37141.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN37141.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN37141.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN37141.1}.
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DR EMBL; QBIY01006302; RXN37141.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498NZ17; -.
DR STRING; 84645.A0A498NZ17; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 2.60.120.1540; -; 2.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF150; ZGC:171445 PROTEIN-RELATED; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 2.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 2.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 2.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..798
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019777455"
FT DOMAIN 127..217
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT DOMAIN 230..398
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 718..793
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 798 AA; 88844 MW; BB8FA99664D59B8C CRC64;
MPMRILFHTV VALQALSLYA TKVFSSDGSS TVTVQSAGDT HHFDVNQDNK LLYQEKQLQN
VPAKYSIEVK GSTCVSVQIA QFYNIPTPTE AKTLRIDAKI EGDCKKTFGQ DLLLNFTVTY
NGPQARSNMV IVDIKLLSGF TADTSLLELQ RLSRTSLVER LDSKDDHVIV YLKEVQKNIP
VNLQIKLKQV LPVKNLKPAV IKVYDYYQTS DQSEMEYSSV LMSFMVTFPA VIESQSEAKL
CASLLKPNES LVMNIYLLDG DQSTLLLQEK AEEEFHRCFN FQVLSRGVIV HHGYEKVEVK
SSDGAANGSV SFKLSVVLDM APAVQILAYC VLPSENVVAH SRDFWTEKCF KNKMSEMGCA
SFTLDTSVFF NSTNEIFLKE HLTVRVKVTE EGTGVLNITV SAEAEASQTV CDNEIVSVPE
RGRIDTVTRS LLVQAEGTEK TETYSWLLCP KGDSLSEEVD LTLPKDVIEG SARSSVSVIG
DILGRALRNL HGLLQMPYGC GEQNMAILSP NIYILQYLEN TEQLTSAIRE RATGFLKNGY
QRQLNYRHNS GAYSTFGHGD ENTWLTAFVL RSFGKAQKYI FIDPQIIQSA KKWLISRRDS
DGCFIQQGKL FNNRMKGGVN DNVTMTAYIT ASLLELETPV TDPVVTKGLS CLRSVIEDVK
NTYITALLAY TVSLARDTDT RQQLFKKLQD VAISEGSHLH WSQSGSAGDS DSLAVEISSY
VLLAVLTTDS VTTADLGFAN RIVSWLVKQQ NAYGGFSSTQ IKLKQVLPVK NLKPAVIKVY
DYYQTSDQSE MEYSSHCE
//
