ID A0A498P2U4_LABRO Unreviewed; 919 AA.
AC A0A498P2U4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Leukotriene B4 receptor 1-like protein {ECO:0000313|EMBL:RXN38521.1};
GN ORFNames=ROHU_001034 {ECO:0000313|EMBL:RXN38521.1};
OS Labeo rohita (Indian major carp) (Cyprinus rohita).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Labeoninae; Labeonini; Labeo.
OX NCBI_TaxID=84645 {ECO:0000313|EMBL:RXN38521.1, ECO:0000313|Proteomes:UP000290572};
RN [1] {ECO:0000313|EMBL:RXN38521.1, ECO:0000313|Proteomes:UP000290572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DASCIFA01 {ECO:0000313|EMBL:RXN38521.1};
RC TISSUE=Testis {ECO:0000313|EMBL:RXN38521.1};
RA Das P., Kushwaha B., Joshi C.G., Kumar D., Nagpure N.S., Sahoo L.,
RA Das S.P., Bit A., Patnaik S., Meher P.K., Jayasankar P., Koringa P.G.,
RA Patel N.V., Hinsu A.T., Kumar R., Pandey M., Agarwal S., Srivastava S.,
RA Singh M., Iquebal M.A., Jaiswal S., Angadi U.B., Kumar N., Raza M.,
RA Shah T.M., Rai A., Jena J.K.;
RT "Draft genome sequence of Rohu Carp (Labeo rohita).";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN38521.1}.
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DR EMBL; QBIY01004775; RXN38521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498P2U4; -.
DR STRING; 84645.A0A498P2U4; -.
DR Proteomes; UP000290572; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004974; F:leukotriene receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903:SF186; GTPASE IMAP FAMILY MEMBER 4-LIKE-RELATED; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF04548; AIG1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01476; LTBRECEPTOR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51720; G_AIG1; 2.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:RXN38521.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000290572};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 574..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 612..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 825..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..196
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT DOMAIN 268..473
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT DOMAIN 591..842
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 873..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 919 AA; 100725 MW; 3E8A39AB7565545D CRC64;
MSAETKIILI GKTGDGKSST GNNTILGEQA FTPKASANTV TTKSVVKDGM VDGRKIRVID
TPGFFDTDRN DTEIKSEIVK ALIECSPGID AFVLVLKVGR YTRHENEVFH QFLNTVKEDA
LKHTVILFTF GEQLEGQTIK EFVKANSQLQ ELVDKCGGRC HVIDNKYWNN CVQVKNLMET
IDKMELMKAK VAVETGVVAG GAGAAAGAAA GGAGAAVGAA AGGAGAAGAA AGGAGAAVGA
AGAVETRAVA GGAGAAAGVG VSATCASMPK RRIVLLGRKG YGKSSAGNTI LGEKVFTPRA
SDNSVKAQCA RREKRRYGRK ITVIETPGFF DTDNDDKEMK SEIIKALVEC APEVDAFVIV
LKVGEYTSQE MKVLQRHLNK INKDVFDHTV ILFTFGKQLK GKTIKEFLKA NSQLQELVDK
CGGRCHVIDN KSWKKRKWGN KSNSAQVKNL LETIDKMRNK NGCFTNELFR KIEEQIQEQI
GKMDGENLPQ DEKRKKAKKN VQNKMLEQAA KATAETLTGA LLGAGIAKMN LNGILSFSSL
LHVSSSFIPN TLSSPSLNMS TQHTTNIMTN RNGAIAGVAI LGLVFLLGVP GNFFIVWSIL
ARARRRSITT LLILNLAFAD GFLMLLTPFF MVYLAQRSWI FGLMLCKVLF YLCCANMYAS
VFLIMLMSLH RLVAIVWPKR VGALTERRML RRLLAGLWLL ALGLSTPVLV FRTIISSNDN
QSLVCDCQHP KPQYEVMQYG METLLAFLLP YGVIIGSYMC ILRRIRKTRF RRRIRSEKLI
LVIIITFGLF WLPYHIINTV QVAAALHPNS ETQTWLKKIR ANLRALTSTV AFVSSCINPV
LYTFAGKSYI RREGLAFMAR LFEGTALETT RRIRRSNQNS RDREKETDEG DSLKDKDSDS
TTTANLNSAI KVVAQKNGK
//
