ID A0A498S5C7_ACAVI Unreviewed; 2187 AA.
AC A0A498S5C7;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=C2 DOCK-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=NAV_LOCUS1606 {ECO:0000313|EMBL:VBB26776.1};
OS Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB26776.1, ECO:0000313|Proteomes:UP000276991};
RN [1] {ECO:0000313|EMBL:VBB26776.1, ECO:0000313|Proteomes:UP000276991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; UPTC01000142; VBB26776.1; -; Genomic_DNA.
DR STRING; 6277.A0A498S5C7; -.
DR Proteomes; UP000276991; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd11695; DHR2_DOCK_C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000276991}.
FT DOMAIN 656..821
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1707..2161
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 178..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1463..1483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2187 AA; 245726 MW; BF52ED24601A43D2 CRC64;
MTAADVRRHI MTGSLLLHPQ NATQMDMTDS SPQAINLIEI VEPLDVEDIL SQRKSNSSIH
EHIASNSNLR RMAEFPADDI EVRLVHRDQL TVESPFPSNL SGVDPLVKDI MQTYNDNFSL
VQRKYFQYSS GEAYIRLLME RPIIAQTTPK QIFEVDSDRP IGRSVSIAGE DQITKRDSFG
SHYSSDSMCT VGSSSGGTNR DDTLRAPHQL HSSASDPTVP GVVQRISNTQ LDQINEARRR
AHRQNALINL LPSQLEADVI ERRSAAPFPV EHTGQKLFIK VLQLQLEPSF EPVFGTIVLY
DLKERRKISE NFYFDLNNDS LRAMISQHAD CIDEASKCTQ AVFSISQPLN DIFIVIKLEK
VLQPCEVADA CEPYLKEDKN RERLMQTAQQ YCERLGAFRM PLGWFAIDLN QILNGSYYPE
KAEALMATIP SSVAVQDVTP ASPTFFDVES IISMDRISNS TSGTFRRVGS GTSSGAAYVG
AQQSQKNRTP LQKRKLFAGL HLTISQNETA AVGLGLETDS LLKDSGSPLT SLSNLQPLLL
NLNSFFRQEA ERLTDEDLCK MLADCRKGGS KLAKLKTFPI AFKMELSGGC GESLMRYQFC
CKFYILYFRF AISSVFRLTP ELLRVHPFVS NNPADIVKEI LEFPSKGIYA VNAIYRNLLY
IYPHSVNLSS RSGPSRNIAI RVELMNAQEK PVYAIFGKSS GPNITFFADT AVSYHNKTPS
FYDEIKINLP VDLNDGHHIL FTFFHITCKP NKVGDEVKIP IGYSWVPLLK GGRLQTGEFT
LPIALEQLPQ SYGYLSPDVN LPNIRWLEGH KPLFDVKLEA VTTVHTQDSH LDKFLLAYQS
LSVNDKKNPP VSEADLKHAI RSVIKARPEP MVAFLYVILD KLLALIANPP YTDVLIHFKC
CPSFTVSVSA VCFEVLGQLV KICTVLLNSF RDAHGRSSLL TTYIHYHKIS LKDLETSIVQ
PNNGKTELKS EGTLRMPTSP ESKHLLDIIK EFERTNYMKA STEGDCELNT SKKVMHEELA
LQWVISGGAA REMAFLNSWF FLELMVKSMA EYLSLSNRLY LPRKLRFREA FIQDLNALSQ
AIISEVIQRT SKDPRQSQSI STSWAYFLRD CFSLMDRTFV ITLIREFNRE IAAKIGNCTE
LCVMPTLMLI KLDFLRIIAS HEHFVVLNLP FGSGNMQGMS TSHSGGSFHS ATSAFSSSSE
GSANLSVSLH HSSSRQSSSP GNSSISSRSS SQVNELHGAI GSAELTIEFR SRHFLIGLAL
ADLASVLETS NTLLHSRAIS LIRNLLSSHE LDVRLLDNTV KARVASFYTT ETNDGPFISD
KVMLAIGGMN FSPPCSPRTE RKHIGLVRPS LSLENTRQLL ACFCWTLKNM ERSSLRQWIR
DLSSNRILQF LDVLQLAVSC FEFRSSLFCS NQDSSETAGE VKDESGNIEG SSIKELGQKK
IRSVPDSENG VRWRKEIKDS QGKGSWKSCT GSSGGQSNDE PIPNDEDVTL EATLCTEIPL
IVLDTLELVI RVVSVLGSDY LFYVLPSVLK VLMHILACNQ SVQTLENVFA SQRAIVTKYP
DLLFEQETEQ CGELCLHLLR HCASRLPAIR SQAAASLYLL MRQSFESGAS FSKVKMQITM
SLSTLVSTGT KHGDWINEDC LRHSLKTVLT YSETDASIDS QLRSTTFSEQ VKDLVFNLHM
ILSDTVKMKE YTNDFEMLID LMYRVAKGYQ NNPDLRLTWL INMANKHSAR DNAAEAAQCM
LHAAALAAEY ISMREYDVHI PKGAAAFQAI SDNILEESAV SDDVISPDEE GICESRHFTQ
NGLVHLVEKT AQFMEKAQMY ESMVQLYKII TPILEENRDY QRLAQIHGCL SQALSRIEPT
VSLIEDIVDA WYSPLPSADR RCFGTYFRVG FYGSRFGDLD GVEFIYKEPA ITKLSEISHR
LDSFYTDRFG KGVVEVIKDS NSVDPNRLDS TKAYLQITYV EPYLENWERR RRPTHFERNH
KLYRFVYATP FTKDGRAHGD LKDQYKRRTV LATQYCFPYV KTRLRVVNRE QNILTPIEVA
IEDVQKRTRE LAAATAQDPP DAKILQMVLQ GCIGTTVNQG PIEVANVFLT NMVLDESGKP
MDKFQNKLRL CFKDFSKKCA DALQKNKKLI QADQQAYQNE LQKNYIEFTK RMAPIVGIRK
NKCSEAHTLK TVHAVAAAAE FGPVTAV
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