ID A0A498SDM4_ACAVI Unreviewed; 849 AA.
AC A0A498SDM4;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN ORFNames=NAV_LOCUS3884 {ECO:0000313|EMBL:VBB29075.1};
OS Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB29075.1, ECO:0000313|Proteomes:UP000276991};
RN [1] {ECO:0000313|EMBL:VBB29075.1, ECO:0000313|Proteomes:UP000276991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; UPTC01000530; VBB29075.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498SDM4; -.
DR STRING; 6277.A0A498SDM4; -.
DR Proteomes; UP000276991; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 4.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000276991};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 46..215
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 216..407
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT DOMAIN 652..702
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 849 AA; 96649 MW; C4F8E276F792F11A CRC64;
MSTRRAEIMK INEFEEKEIG MLAGALSAPH QPPHDQLHSL SSTLPVFILI KQLLLQWKLY
EAKEEKTPGN SGFMIEISSA TNTSDNNPEG YAPGDSYIVK LRGWRTKFTV QAFRGFGIYA
QFENGEHAGK FDLQGKKGEA RIAPNCRKAG VSHSNLRPKT SVHVLWHAPE TSEKGCAYFR
ASVITSRKIW YGDDGPLTKK FCVREGYKKM LTIDEDNLDC CACDEAKYDL EFIGLWSRDT
HPKDYPSLEH LTHFTDMLGA SHSSNYTMWK FGMIATDGMK EIAEWGNTYK GEQEMKANAK
EIRTLMKIKG LWYPEVQGRT TSSFVVNKYH HLASLAAMFG PSPDWCVGIS SVNLCLPDCT
WIPERTFELL PFDAGTDNGP TYMSPNNPAE PRIPIHPITT KLDKRSPFYN PNSDIIAPLA
RLKLTRKEVM KSVCKTVDEY QTEAYNVTST SEDEEYKDRR ECMVTNWEPW SLCSATCGKG
IRMRSRVYVF PIKAQMFRCH RQTIERQFCN AEISECHDSD AFNSKCSVSS WSSWTECSVT
CGHGTRSRSR IFKELDSNNN TCPNVDLVRK DICTGDNGDD CSVTPDPLCR ATSWSEWSPC
SASCDHGIHV RTRLLFYAEH EERCANVNLL EKENCQLQTC RRLLSVHSKE ICMEDKQEGQ
CAGTFPRYWY NSKLKRCERF IYTGCKGNRN QFETEDDCKR MCLEYYGSSV GEVVPGHQLV
NEFGVDQVND GGPPVDCVIS EWTPWGNCSA TCGSGKRKRS RQIEIFPRNG GRSCPEHMVQ
ELRCELRPCA IQNCHIKPWT MWSPCSVTCG DGKQIRRRRI IRPHRYVDDE EDSPCNAPEK
ESRPCHVKC
//