ID A0A498SDP5_ACAVI Unreviewed; 2566 AA.
AC A0A498SDP5;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=NAV_LOCUS2010 {ECO:0000313|EMBL:VBB27180.1};
OS Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB27180.1, ECO:0000313|Proteomes:UP000276991};
RN [1] {ECO:0000313|EMBL:VBB27180.1, ECO:0000313|Proteomes:UP000276991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; UPTC01000194; VBB27180.1; -; Genomic_DNA.
DR STRING; 6277.A0A498SDP5; -.
DR Proteomes; UP000276991; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05170; PIKKc_SMG1; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR031559; SMG1.
DR InterPro; IPR039414; SMG1_PIKKc.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF71; SERINE_THREONINE-PROTEIN KINASE SMG1; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF15785; SMG1; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Reference proteome {ECO:0000313|Proteomes:UP000276991};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1951..2296
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2534..2566
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2482..2501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2322..2356
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2566 AA; 292278 MW; 2D00BE34C18CCE96 CRC64;
MLLTMNGMEV QQAKIVEVKS LVYRIVNDKK NYTKDERIAA CEQLQQTLTH ANDVANIGYD
WKKLVEDLLY CIKTRQQIEL KRCISDCLGS LGCIMFSQYN EYLKLMLNEA KLIPDKYEDD
RALVLKAIFS SLNLIGTFAW QSRIRPQDID SLMIAIKNWL EVNDSSVVLI SLLDTCLAVS
KYFPAVFKHS FDDVVDFTVG WYIEPEQPIA VLDKCYQMLI ELRPYWHSAV PSAVTLMKQF
LDDASAYIED IKVNEAKPEN MLSKTAAILR ALITMLEVMN IPVNSLVADF AEKVFGRIVR
LLTHLDNVFV AKIGSVFGYM AEVLCITLKT YPKLDFLVNS MKAMKIMLEH PSVNEKTMLK
ILECNGKIID SVTPKMVVEI VDYVIGDGGP LNYVIIRSQE VMQAYGNVLG KLLAPKNLST
LQVAYNRVRE DVRSCLNMLQ ATEAEEYCSS SLLIEKKLMI YFNALYSLGI VKNSLIAMMG
LSPSLFAFLM TETPITKKEF IINYPGCHYA LLYIVKMHSE KHENFVANSS LLIDKNSLTL
VAEPATAKHT TTILNVVTKL LAIDDLLWTD TRNLLVDWIH GLVFSLTPDV LQHILDKPEI
IEMRTALLDS FVRHSLPKKT PLDKILCNSE VFVVHGCTAA TSHRVRHFTL LRRLAVFNLV
KNGKPEMTMK FVKHVFDQCH SGCQNKITGI WQATPPVIFI SNGLTEYAQD LMEFGQQKIP
ESLFTPEHFK IVADFLLNSV LPTYCFNSVD DGNWILDTAA TIYADAMGDI STNNDCISKW
RWIIAQMAQF CVNNRLKTPL GKPLSTFLAF ENEIRRLASN ALSRKPLPVG KVVKDEIVQK
TVTMSGRGVV EDEDEAEMEL ERETRQLTTS EQWWRVRALL DMIEMLDKLM AYVCHGAIFQ
LSTVSQLSQQ FLTTNQASCA NWLSRLCLPM MAVAYTSNNF AQVIRLGGCS LRDIEKRVEE
KESRDNIDEK GEIDSVTHTC IMWMVKALID LGRPQAILGL YAWVKKIYGK QYVWIKCAAQ
MAAGRIESAL NGLQECLRNG NLSENIQKTI RQLIIFGLEA LRNSEEIDIF WRALYGVLDP
KSDEIPDGFE EIAWKRMKSL TTFDNYLKNE SFLSIPWDIR NSFIHTELKL MDIVHDRFRD
SKDNKIDVVD LTRQLSEDSR ILMLADTSLQ TFTRASALHL LATAVKDSRK PYHKQSVTAN
VVDPSFLFDW KNGPPIQRLM IGQQLSSWLQ NTQTRESGGC SSLRVISNEA AYHLEMARLA
RKTKNYRLAE KHIKIHYNKR LPTLDSFQLS ILRGMQGNWI NGAADKENNL TNNLVVQLPM
QQRLYNFENL MSSYGFSKTM WAISETADTD CARTFLQGKA FSLLMSAVAD EIDRLIYKSN
LMFNGTPTVA PDALITVLTQ QLNHTTIEDS AVLSMGPNIG VSNQQQLEQS KILAKAIVQL
ARWLQMESSL LPVAMGHSMR IAFHIFGVEQ SQLPLLGASG IIDSLAGALL STSCKLSPHL
AKAHLELGNW AFKRVTNADN EIKLSFISEE CDTVKWQIKN ACTSVEDSVI ENLLQTVQKS
TSLTSILSDC KAIAGNAVSE QTCDMLFGPR SIIQEVWRGA NSRHLAFCTC AVHSYFAYIA
VSGRETKEGT IGVVMATLRI LQLLVKQYDA LHHLILNEML QINELSWKDI LPQLFARLNH
PVRAVRDTLC TILERIAATS PHALCYPAIV GATQPIVIHN EYVDNGEVEK NDFVDVIDEE
KKKRADQDRS LMFECCQRIV TQMQALFPEL VKDVTEFVKE LQRIDMLHEE RWTFVLTNLD
LEMNRRILQI ETEMMKTLMN THLNDDEKKE IIHEKTVIFT SLVYRIVEDL YEKTCTSTPV
TVNEKQFQDT YLATIEEAMK TLRMKRSEPR QAWASFKLLL TQFNQRANRR SFVCLQMADI
APRLTALNKT HVPLPGQEHK NFSDVVTLER ISKQTVILPT KTRPRKVIFH GSDGKDYPFL
FKGQEDLHLD ERIMQLLRIC NLMLLTKETD WPSYVAENYS VIPLGSRSGL IEWVEGATPI
FQVYRKWQLR QAAENTSNQK INEVERPSAL FFKKLRAAFQ SNKIPKESIT DRQKWPFLIL
KGVVEDLIEE TPRDLLSREL WLRAGSSDTW FRVTERFARS TAVMSIVGSI LGLGDRHLDN
VLVNFEFGHV VHIDYNVCFD KGRNLRVPEM VPFRLTGNIV RALGPTDVEG TFRLSSENVL
KKLRAGKEIL LTILDAFVYD PLVDWAAAQD DLGSRSMIGI ATIIAVYGVV DRHSDILHAM
AFSLFALRIK EFSAAWLDNK DHLKRMLVSV VRILGKLHEN VQKDMESRSQ NWEEEANKLE
MEKLSIERDL KNAVTEHHSM MHDIRPLLRS FAHAKTVWRI CLTKKFTSLF LKFVRESLMN
LMNQKCLNGT KNESFAIYLQ RYKELFIEPL IKGLKLLDDA YSSANICIDL FRTVIDNIPS
IYDNLLLLQK VKERMGLPFC SGRSPPMERR EGQQQQNIHG KHVSKRVRMK LEGMIVNGTN
KNDNAKSDAN IISEPLTPSE QVDLLIQQAT DISNLALMYE GWTAWV
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