ID   A0A498SEK9_ACAVI        Unreviewed;       901 AA.
AC   A0A498SEK9;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VBB30331.1};
GN   ORFNames=NAV_LOCUS5122 {ECO:0000313|EMBL:VBB30331.1};
OS   Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX   NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB30331.1, ECO:0000313|Proteomes:UP000276991};
RN   [1] {ECO:0000313|EMBL:VBB30331.1, ECO:0000313|Proteomes:UP000276991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   EMBL; UPTC01000847; VBB30331.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498SEK9; -.
DR   STRING; 6277.A0A498SEK9; -.
DR   Proteomes; UP000276991; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd21214; CH_ACTN_rpt1; 1.
DR   CDD; cd21216; CH_ACTN_rpt2; 1.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd00176; SPEC; 2.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF442; ALPHA-ACTININ, SARCOMERIC-RELATED; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 3.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 2.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000276991};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          42..146
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          155..263
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          759..793
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
SQ   SEQUENCE   901 AA;  105727 MW;  6DC8026293D491EE CRC64;
     MVEYYQQLPP NNYNYQQQPG YDYTQQEEEW DREGLLDPAW EKQQKKTFTA WCNSHLRKAG
     TSIEVIDEDF RNGLKLMLLL EVISGEALPR PDRGKMRFHK IANVNKALEY IESKGVKLVS
     IGAEEIVDGN VKMTLGLIWT IILRFAIQDI NVEELSARDG LLLWCQRKTA PYNNFICFNN
     DKIFSWKDGL AFCALIHRHR PELIDYSKLH KGDPLHNLNL AFDIAEKYLD IPRMLDPEDL
     VYSQKPDEKS VMTYVSCFYH AFRGGHQTET AAHRISRVLK VNQENEKMME DYERMASDLL
     DWIRRWMPWL SNRSSNESLE TIRKKLNDFR NYRRHEKPPR VEEKGNLETL FNTLQTKLRL
     SNRPVFLPRE GHLIKDINAA WRGLEDSEKG FEEWLLSEMM RLERLEHLAE KFRRKCALYE
     EWAHGKEDAL RSSDWKSCGL YKIKSKFHNI KALRKRHEAF ESDLGAHQDR VEQIAAIARE
     LNNLRYPDIG PINARCQNIC DQWDRLGNLS QQRRRQLEEA ERVAEHLDRL YLDFAKRVAP
     FNNWLDGARE DLADIVIVHE MKEVQELLNA HNHFKSTISD ADNEFRTIVN IERHGLDREL
     LRNPYTDLSG ADIRRKWQEV QQSIPKRDAQ LQNECHRQQN NERLRQLFAE KANTVGPWLE
     RQLEHVLSIG LGGRGSLENA VSQLKSIQQQ TFNYKPKLEE LERINQEMQE NYVFENRAAR
     YSMESLRVGW ESLLTSINRT INECENQILM CNSKGISEEQ LNEYRSSFNH FDKDRQGLDP
     EQLKSCLISI GYNIRPGKEG DHDMSRILSV VDPNRMGRVP FNAFLDFMTH ETGDADTVEQ
     MIESFKILAG GKPYITAEEI RRELHADQAE YCIQRMQQFQ APNGPPGSYN YVSFSKSLYN
     Y
//