ID   A0A498SFZ6_ACAVI        Unreviewed;       556 AA.
AC   A0A498SFZ6;
DT   05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=inx {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=NAV_LOCUS3666 {ECO:0000313|EMBL:VBB28837.1};
OS   Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX   NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB28837.1, ECO:0000313|Proteomes:UP000276991};
RN   [1] {ECO:0000313|EMBL:VBB28837.1, ECO:0000313|Proteomes:UP000276991}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
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DR   EMBL; UPTC01000483; VBB28837.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A498SFZ6; -.
DR   STRING; 6277.A0A498SFZ6; -.
DR   Proteomes; UP000276991; Unassembled WGS sequence.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF9; INNEXIN-7; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000276991};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        288..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   REGION          522..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..545
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  64562 MW;  AC983D58DBE1C399 CRC64;
     MSFVFHILHT VPYSNKPIVK DVIASLHSYF TCNLLIAFSV IISFKQFGGR PMECMLPMGF
     SGAWEQYAEN FCWAQDTYFI PPKVFVEHIS AEERRERRIS YYQWMPFFLL FQAACFKAPT
     LIWKYFAGQS GMKLGQILRL ASDPANSSLE VKKGNIEALC VHLQGALRFH ERVKKKKLVP
     HKIFRFLNLK YANYYVATIY ILAKLAFLAN AIFQISLMTR YLLPEFKNDK GLESWMNIIW
     PKNISPSWHH SGIFPLVTLC DFEVREMGNI QTHTVQCVLV VNLFTEKIFI LLWSWFIILA
     TVTSLNVLNW IYLLTENCSK EHFILNHLEM SGIPFDKNDP QNKKHVDRFL HKYLGTDGIF
     VLRMVANHAD VVFATELIAS LWQSHYVFEE RRKNISQMDK VWPQHQQRLE MALLEEAQIA
     RKISSDALNA VQRKRSVFYD SPYFVKRGPL TGITIPKVPS RSILGNSYVL SRNNSKDSMV
     PFSPRLGNQS RGSIFSTDSQ SKLRRRHSLE KIDIISGGRV KKFADSSDEE EKEKEREKEK
     GPKSLNMSRK NTVKIW
//