ID A0A498SNL1_ACAVI Unreviewed; 904 AA.
AC A0A498SNL1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Latrophilin Cirl {ECO:0008006|Google:ProtNLM};
GN ORFNames=NAV_LOCUS6365 {ECO:0000313|EMBL:VBB31574.1};
OS Acanthocheilonema viteae (Filarial nematode worm) (Dipetalonema viteae).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Acanthocheilonema.
OX NCBI_TaxID=6277 {ECO:0000313|EMBL:VBB31574.1, ECO:0000313|Proteomes:UP000276991};
RN [1] {ECO:0000313|EMBL:VBB31574.1, ECO:0000313|Proteomes:UP000276991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UPTC01001290; VBB31574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A498SNL1; -.
DR STRING; 6277.A0A498SNL1; -.
DR Proteomes; UP000276991; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF473; FI21270P1-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 2.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000276991};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 575..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..142
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 494..627
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 802..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..839
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 101107 MW; 9F607983400EE081 CRC64;
MRCSIPVNNG QLGDPCPDTE KYLDVEFKCS KKPDIVKATI STSTATTFNT IAATNQTLSI
IDLMESSIGI EFTTIKLSDN DGKQLFCDAI TERDIDWAQT EFGMIARVPC PIGSTGYAEW
MCGSDGHWQS DGPDLSRCIS TWSKGLLLDA EEVDNPVYRL EFLHEIQQRT RRESLIGGDL
IALSRALKLL IPITIYESDA DKFVELVVES VNNIAKESQI LAWNDLKGVK RRVVADQLMS
VVDQVSMTIS ALITPDTPRI IMKPNADVEL EISAVRVHDY VAFPSTSLYR TTDDTINIPQ
EALTLRNNAI DEAKILYVAY SSIGKYLQPE PRQTADGTMV PRQIASKIVS LSIINSDNKI
ETIDHLRKPV IITFSIEDRV NLSMPQCVWW NRTRLQWSSY GCTVSLHNAT HTICHCNHLT
YFAVLMDVHY QELPIGHNIA LTFLTYAGCT ISIICLLLSL FVFQCFGTSG GDRIFIHKNL
CFSLLIAEAL FLGGFPLSVV AISIWFDRFS YGTERYCWLR SDNYFILAFI GPVVIILLCN
TVFLVMTLFI VCSHSSIGYT PCKQDRNALR NVRKWLKGSI ALVTILGLNW IFGFLWVDEQ
SIVMAYAFTI MNSLQGLFIF LFHVIFNDRL HKDYRKWMKH VSWVPNCMRD DSSHTSRTMP
YLSTNTSKTG QAVSSSSSTA SELLRFTKSF GGKSDEYSPL LASQRTGLIH EQIHYPSMSE
KYPALPAPRM VAAIDPRYNN SVQMLLARQC CNSNGLCDYA TISYDDLCTS SSNYYHQPQQ
NQYYLNCMTP VTFVPNANLS STTTIPPELR TLHFRPPPNF PPPPPPPPPP SPPPQPSSTS
LLPSTHHSTT PISAASIARV SDDSAYSDSS ASTLQCHGEV ITNRSGMLLR MDLSKNPPVF
VQGL
//
