ID   A0A4D6HEX6_9EURY        Unreviewed;      1478 AA.
AC   A0A4D6HEX6;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=PKD domain-containing protein {ECO:0000313|EMBL:QCC51718.1};
GN   ORFNames=DV733_10940 {ECO:0000313|EMBL:QCC51718.1};
OS   Halapricum salinum.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Halapricum.
OX   NCBI_TaxID=1457250 {ECO:0000313|EMBL:QCC51718.1, ECO:0000313|Proteomes:UP000296706};
RN   [1] {ECO:0000313|EMBL:QCC51718.1, ECO:0000313|Proteomes:UP000296706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBA1105 {ECO:0000313|EMBL:QCC51718.1,
RC   ECO:0000313|Proteomes:UP000296706};
RX   PubMed=30975999; DOI=.1038/s41467-019-09390-9;
RA   Xiong L., Liu S., Chen S., Xiao Y., Zhu B., Gao Y., Zhang Y., Chen B.,
RA   Luo J., Deng Z., Chen X., Wang L., Chen S.;
RT   "A new type of DNA phosphorothioation-based antiviral system in archaea.";
RL   Nat. Commun. 10:1688-1688(2019).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP031310; QCC51718.1; -; Genomic_DNA.
DR   KEGG; hsn:DV733_10940; -.
DR   OrthoDB; 8638at2157; -.
DR   Proteomes; UP000296706; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF18911; PKD_4; 1.
DR   SMART; SM00089; PKD; 2.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   SUPFAM; SSF50939; Sialidases; 1.
DR   PROSITE; PS50093; PKD; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000296706};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          124..194
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   DOMAIN          212..278
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          633..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          850..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..687
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        850..868
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1478 AA;  158447 MW;  BAFA078255109ABB CRC64;
     MTDLRSIRYG QTKDGRIGGT DPNYPDLAQW YYEPVSFYGE KGDKVKLTIS SDIFTPIVEI
     VLPDGSKEPF GTLVNPPFED PPLERQETEI LEQTGTHTLW ISHERYTRLG PYQLTLEAIE
     TPNLNARFDY SPLSTSPSSD VTFDASPSDG TIDEFVWEFG DGTEAQGTQV THHYDTSGEY
     KVQLHAKSSV DSINIEDIAS ATVRVEADGN DLVSGFSINN TVPQTNDTVQ FDSGLTEDEL
     ENEDITLTWE FGDGSTAKGP RVSHTYATSG TYTITLTADG ETFTRELTVG TPPVEITGLD
     RDIGGTLLPQ LGIDESVEAT VEVPETSDIE QVQFEFAGQQ SIATNPPYDA SLTIGDVVAP
     ATPLIVQAVT STGATREIEH EIPIQRLPEW LEFLLKSTDT LGVELTDGEI EITYSPLADL
     DVGFDIPKDV LSGDDRPDEG GNGTYDFDVG MGGIYDPLVN EAELTAAGTI AAEVMALAFE
     IKVALTGTVQ STTLALESAQ ADIDSQLEFD IEPPTVPIPV SIPIPGTNSA IGIVPTVIVS
     ADGTFDFNAD FSFDAGTVKP GIELEVSIGI DLELPLLPDG ELKGVPSGGI DGEFDVGTDD
     WNLRATFFLA GKVVLDIPGT EIVLEQDPIW DQPLTGDGAS GSSQVTASSL SDPRVRQTST
     GGPQPLPEID SVQTASLSTQ SISPRESFRL TDRPYEDIQP ALASPTDSKQ LVVWSQQDED
     KSAKAGNDLV AQWYENGSWS DQFVITDSTY ADADPVCAAI ETGEILVAWK RFPEDRTTSS
     DLETLSDVND TRNKTEIAYS IYDGSSWSNP TLLTSTSITQ RRPTVATADG EWYLAWEAFD
     REVGTSTVRS TVVSPDGSTT SITDQGGAAS PDLGSRDDGT VDLAYLVMDN GQVTDITHRV
     RDGTSTISEQ TYSAPEAATV VVANGRVVWA TNIDRNPTLV EAADSSTTEL SLREDVIEVR
     ELSLSARADQ AILSYVSILE GGSTRDLVYR LDRGNGWIFD RSITEDIQDG IRVRYTDLVF
     TGPASFLSGY SVRDPGTDTV SDVFATTQEF GPAYAIDGSV DSGVAGDQTT LSYELENRGD
     IDGSEQVTVK ILRDGTEIDS ITHDPVNSGG TLTRDRDVTI GDGGEFTITV DVPEPSLETE
     PRDISLVAAR AKLRVDEVSA QRPGPNEAVV QIALTNNGGA VADKVPVVLN DAAETVAAPT
     ISQIGAKSTT TIETTLDPQA LDNSDTHEVR IDPDGTLPSQ AETTPLRQTY LVRPELRVED
     VRYREDNDRF VRVLVSNHGP GVGMATVTVR DGTDNELNTT QVSVPPAELD NGQVVSVHRT
     IDISTPSLVE GQAVAVEIDP EVSNRRQEGL TTVQNVETVL PSEYQGTVGD VVVSATGSSL
     PVGGQGTVDI TAENASQVTL EGLWTDWGVE VDVPSEILEV DIAESGTVTL NWGAAQSSVT
     PTVTILIPDR YVGGEYLVNI VASNDNGAVE ATATLTIE
//