ID   A0A4D6HF83_9EURY        Unreviewed;       560 AA.
AC   A0A4D6HF83;
DT   03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT   03-JUL-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=NADH-quinone oxidoreductase subunit D {ECO:0000313|EMBL:QCC52211.1};
DE            EC=1.6.5.11 {ECO:0000313|EMBL:QCC52211.1};
GN   ORFNames=DV733_13655 {ECO:0000313|EMBL:QCC52211.1};
OS   Halapricum salinum.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Halapricum.
OX   NCBI_TaxID=1457250 {ECO:0000313|EMBL:QCC52211.1, ECO:0000313|Proteomes:UP000296706};
RN   [1] {ECO:0000313|EMBL:QCC52211.1, ECO:0000313|Proteomes:UP000296706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBA1105 {ECO:0000313|EMBL:QCC52211.1,
RC   ECO:0000313|Proteomes:UP000296706};
RX   PubMed=30975999; DOI=.1038/s41467-019-09390-9;
RA   Xiong L., Liu S., Chen S., Xiao Y., Zhu B., Gao Y., Zhang Y., Chen B.,
RA   Luo J., Deng Z., Chen X., Wang L., Chen S.;
RT   "A new type of DNA phosphorothioation-based antiviral system in archaea.";
RL   Nat. Commun. 10:1688-1688(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC         Evidence={ECO:0000256|ARBA:ARBA00000100};
CC   -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD,
CC       E, F, and G constitute the peripheral sector of the complex.
CC       {ECO:0000256|ARBA:ARBA00038617}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa
CC       subunit family. {ECO:0000256|ARBA:ARBA00010019}.
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DR   EMBL; CP031310; QCC52211.1; -; Genomic_DNA.
DR   RefSeq; WP_049992537.1; NZ_CP031310.1.
DR   AlphaFoldDB; A0A4D6HF83; -.
DR   STRING; 1457250.GCA_000755225_01593; -.
DR   GeneID; 39848926; -.
DR   KEGG; hsn:DV733_13655; -.
DR   OrthoDB; 43567at2157; -.
DR   Proteomes; UP000296706; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR   Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR   Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR   HAMAP; MF_01358; NDH1_NuoD; 1.
DR   InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR   InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR   InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR   InterPro; IPR020396; NADH_UbQ_OxRdtase_CS.
DR   InterPro; IPR022885; NDH1_su_D/H.
DR   InterPro; IPR029014; NiFe-Hase_large.
DR   PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   Pfam; PF00346; Complex1_49kDa; 1.
DR   SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR   SUPFAM; SSF143243; Nqo5-like; 1.
DR   PROSITE; PS00542; COMPLEX1_30K; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Oxidoreductase {ECO:0000313|EMBL:QCC52211.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000296706}.
FT   DOMAIN          47..164
FT                   /note="NADH:ubiquinone oxidoreductase 30kDa subunit"
FT                   /evidence="ECO:0000259|Pfam:PF00329"
FT   DOMAIN          310..560
FT                   /note="NADH-quinone oxidoreductase subunit D"
FT                   /evidence="ECO:0000259|Pfam:PF00346"
SQ   SEQUENCE   560 AA;  64037 MW;  534DA83321BA1024 CRC64;
     MSLEEPVPDT TEEVGVTEDG LDYDALEALV SEHVVDRESH VNAEAFVVYP DAIQDTLSTL
     KEEAGFDHCS CVTAQEYEDR FESIYHLKKF DDPTQQLSVV VPTTKDDPIS ESAEPVFRTA
     DWHEREAYDL VGIDYDDHPD LRRILLPETW QGHPLGQDYN QNQPQIVPLR EHANPLEQDH
     RAGEDSDTMF INIGPHHPAT HGVLHVKTVL DGEQIADLEP DIGYLHRCEE QMCQQSTYRH
     QIMPYPDRWD YTPGGILNEW AYARAAESMA DIDVPEYAQV LRTMSAELTR ICAHMLALGT
     FGLDVYGDFT AIFMYAVRDR EIVQNILEDL TGQRLMFNYF RLGGVSWDVP EPREEFFEKI
     RDFLDDLPER IEEYHDLVTG NEIFQMRCVD TGVLPPEVAK NYGATGPVLR GSGVDYDLRR
     DDPYGYYDEL DWDVVTEDGC DNYARVLVRM REVEESAKII DQCVDLLEDW PEEERKIQSN
     VPRTLRPDAD KEVYEAVECA KGELGIYMRS DGTDKPARFK IRSPCFSNLQ TLPEMSEGEY
     IPDMVASLGS LDIVLGEVDR
//