ID A0A4D7CR20_9ENTE Unreviewed; 447 AA.
AC A0A4D7CR20;
DT 31-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 31-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|ARBA:ARBA00018893, ECO:0000256|HAMAP-Rule:MF_00377};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:QCI85443.1};
GN ORFNames=FA707_00005 {ECO:0000313|EMBL:QCI85443.1}, FE258_06560
GN {ECO:0000313|EMBL:TLG79988.1};
OS Vagococcus zengguangii.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Vagococcus.
OX NCBI_TaxID=2571750 {ECO:0000313|EMBL:QCI85443.1, ECO:0000313|Proteomes:UP000298615};
RN [1] {ECO:0000313|EMBL:QCI85443.1, ECO:0000313|Proteomes:UP000298615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MN-17 {ECO:0000313|EMBL:QCI85443.1,
RC ECO:0000313|Proteomes:UP000298615};
RA Ge Y.;
RT "Vagococcus sp. nov., isolated from faeces of yaks (Bos grunniens).";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TLG79988.1, ECO:0000313|Proteomes:UP000306774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MN-09 {ECO:0000313|EMBL:TLG79988.1,
RC ECO:0000313|Proteomes:UP000306774};
RA Ge Y.;
RT "Vagococcus sp. nov., isolated from feces of yaks (Bos grunniens).";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP039712; QCI85443.1; -; Genomic_DNA.
DR EMBL; VCAP01000007; TLG79988.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D7CR20; -.
DR KEGG; vao:FA707_00005; -.
DR Proteomes; UP000298615; Chromosome.
DR Proteomes; UP000306774; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00377}; Reference proteome {ECO:0000313|Proteomes:UP000298615}.
FT DOMAIN 143..274
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 355..424
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT BINDING 151..158
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ SEQUENCE 447 AA; 50791 MW; D1EF0329E55AFF5E CRC64;
MPNIDYIWKE LEESYRKILT VPSFNAWIDQ ATPISLVNNQ LTIEVPSSLH KEYWEKNLST
KIVETGFKLT GEEITPVFVI QNNEPIMEDK PKEETTILPE QAMKNGKKAY LNPKYTFDTF
VIGKGNQMAH AAALVVAEDP GATYNPLFFY GGVGLGKTHL MHAIGHQMLM NNPEAKVKYV
SSESFANDFI NSIKNGTSEQ FRQDYRNVDL LLVDDIQFFA EKEGTQEEFF HTFNTLYNEG
RQIVLTSDRL PNEIPKLQER LVSRFAWGLS VDITPPDLET RIAILRKKAD AERLEIPEDT
LSYIAGQIDS NIRELEGALV RVQAFATMNS EDITTSLAAD SLKSLRPISP KNQLSILAIQ
EKVCEYYHID LKDLKGKRRV KSIVLPRQIA MYLSRELTDN SLPKIGAEFG GKDHTTVIHS
HEKIQQLLET DISLQKEVKD IKDLLTN
//
