ID A0A4D9DNF8_9SAUR Unreviewed; 491 AA.
AC A0A4D9DNF8;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Thiamine transporter 1 {ECO:0000256|PIRNR:PIRNR028739};
DE Short=ThTr-1 {ECO:0000256|PIRNR:PIRNR028739};
DE AltName: Full=Solute carrier family 19 member 2 {ECO:0000256|PIRNR:PIRNR028739};
GN ORFNames=DR999_PMT19389 {ECO:0000313|EMBL:TFJ98664.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFJ98664.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFJ98664.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98664.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98664.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFJ98664.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98664.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98664.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: High-affinity transporter for the intake of thiamine.
CC {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
CC Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR028739}.
CC -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC 2.A.48) family. {ECO:0000256|ARBA:ARBA00005773,
CC ECO:0000256|PIRNR:PIRNR028739}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFJ98664.1}.
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DR EMBL; QXTE01000377; TFJ98664.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DNF8; -.
DR STRING; 55544.A0A4D9DNF8; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015234; F:thiamine transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002666; Folate_carrier.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR028338; ThTr-1.
DR NCBIfam; TIGR00806; rfc; 1.
DR PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR PANTHER; PTHR10686:SF19; THIAMINE TRANSPORTER 1; 1.
DR Pfam; PF01770; Folate_carrier; 1.
DR PIRSF; PIRSF028739; Folate_carrier; 1.
DR PIRSF; PIRSF500794; Thiamine_transporter_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR028739};
KW Glycoprotein {ECO:0000256|PIRNR:PIRNR028739};
KW Membrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR028739, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR028739,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR028739}.
FT TRANSMEM 21..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 491 AA; 55645 MW; 9D692052F654198E CRC64;
MEARAGLRAL SLSGRAPRGR CWALPTALLC LYGFFASLRP SEPFLTRYLL GPDKNLTETQ
VFNEIYPVWT YSYLVLLFPV FLATDYLRYK PVILLQGLSL IVTWFMLLYA QGLLAIQFLE
FFYGLVTATE IAYYSYIYSI VDLNLYQKVT SYCRSATLVG YTVGSICGQV LVSVANWSLF
SLNVISLTSV SVAFATAWFL PMPQKSLFFH HVLRSQVTRE MKVLDCKNGA VIQDDPALKR
VPGWEDIESK VPLNAEEHSA ETQEQKVDIS KVLRELWRDF LQCYSSRPML CWSVWWAFST
CGYFQVINYT QGLWEMVLPS QRFEIYNGGV EAVSTLLGAV AVFAVGYIKV SWATWGEVAL
ALFSLLIAAA VYVMDTIRNI WVCYASYVIF RIVYMLLITI ATFQIATNLT MERYALVFGI
NTFIALALQT LLTLIVVDSS GLGLNIFTQF MIYASYFAAI SLVFLVSGIY SVMKNYRRQE
EMPSRSTTSP P
//
