ID A0A4D9DS26_9SAUR Unreviewed; 838 AA.
AC A0A4D9DS26;
DT 03-JUL-2019, integrated into UniProtKB/TrEMBL.
DT 03-JUL-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Axin-1 {ECO:0000256|ARBA:ARBA00013892};
DE AltName: Full=Axis inhibition protein 1 {ECO:0000256|ARBA:ARBA00032466};
GN ORFNames=DR999_PMT19945 {ECO:0000313|EMBL:TFJ98139.1};
OS Platysternon megacephalum (big-headed turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Platysternidae; Platysternon.
OX NCBI_TaxID=55544 {ECO:0000313|EMBL:TFJ98139.1, ECO:0000313|Proteomes:UP000297703};
RN [1] {ECO:0000313|EMBL:TFJ98139.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98139.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98139.1};
RA Gong S.;
RT "Draft genome of the big-headed turtle Platysternon megacephalum.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TFJ98139.1, ECO:0000313|Proteomes:UP000297703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DO16091913 {ECO:0000313|EMBL:TFJ98139.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:TFJ98139.1};
RA Gong S.;
RT "The genome sequence of big-headed turtle.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TFJ98139.1}.
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DR EMBL; QXTE01000422; TFJ98139.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4D9DS26; -.
DR STRING; 55544.A0A4D9DS26; -.
DR Proteomes; UP000297703; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd11582; Axin_TNKS_binding; 1.
DR CDD; cd08707; RGS_Axin; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR043581; Axin-like.
DR InterPro; IPR014936; Axin_b-cat-bd.
DR InterPro; IPR032101; Axin_TNKS-bd.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR46102; AXIN; 1.
DR PANTHER; PTHR46102:SF3; AXIN-1; 1.
DR Pfam; PF16646; AXIN1_TNKS_BD; 1.
DR Pfam; PF08833; Axin_b-cat_bind; 1.
DR Pfam; PF00778; DIX; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00021; DAX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000297703};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE-
KW ProRule:PRU00069}.
FT DOMAIN 88..211
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 756..838
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 389..426
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 94425 MW; 548EEFFA4A719010 CRC64;
MNIQGKGFPL DLGGSFTEDA PRPPVPGEEG ELVSTDPRPI SHGFYSGKSD VIKNETSTAT
PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIN LFRTFLKQED CADLLDFWFA
CSGFRKLELC VSNEEKRLKL AKAIYKKYIL DNNGIVSRQI KPATKSFIKD CVMKLQIDPD
MFDQAQTEIQ CMIEDNTYPL FLKSDIYLEY TRTGGESPKI YSDQSSGSGT GKGLPGYLPT
LNEDEEWKCD QDIEEETSRD SAPSSRLTQK LLLETATQRA TSTRRYSEGR EFRHGPWREP
VNPYYVNTGY ALAPATSAND SEQQSMSSDA DTMSLTDSSV DGIPPYRLRK QHRREMQESA
KANGRVPLPH IPRTYRMPKD IHVEPQKFAA ELINRLEEVQ REREAEEKLE ERLKRVRAEE
EGEDADISSG PSVVSHKLPS AQALHHFTPR YSEMGCAGMQ LRDAHEENPE SILDEHVQRV
MKTPGCQSPG PGRHSPKPRS PESGQAGKMQ GTIPPGHGKH ATKSGMKLDA ANLYHHKHIY
HHIHHHSVMK PKEQIEAEAS QRVQNSFAWN VDSHNYATKS RNYTESMGLA PNPADSLGYS
GKASLLSKRN VKKTDSGKSD GANYEMPGSP EDVERNQKIL QWIIEGEKEI SRHKKTSHGS
SGAKKQLAHD MPRPLSIERP VAVHPWVSAQ LRNIVQPSHP FIQDPTMPPN PAPNPLTQLE
EARRRLEEEE KRAGKLPPKQ RLKPQKRPGN GASQPCENIV VAYYFCGEPI PYRTLVKGRV
VTLGQFKELL TKKGNYRYYF KKVSHEFDCG VVFEEVREDE ATLPIFEEKI IGKVEKID
//
